1-(2,4-Dichlorophenyl)-2-[4-(3,4-dimethylthieno[2,3-b]thiophen-5-yl)pyrimidin-2-yl]sulfanylethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,4-Dichlorophenyl)-2-[4-(3,4-dimethylthieno[2,3-b]thiophen-5-yl)pyrimidin-2-yl]sulfanylethanone
• 化学式: C₂₀H₁₄Cl₂N₂OS₃
• 分子量: 465.4
• InChiKey: URZOPUVJQRERTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  125
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Compounds and compositions for treating fibrosis
  申请人：YALE UNIVERSITY

  公开号：US11504373B2

  公开（公告）日：2022-11-22

  The present invention provides compounds and methods for treating, ameliorating, and/or preventing a MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease.

  本发明提供了用于治疗、改善和/或预防 MKP-5 调节疾病的化合物和方法。在某些实施方案中，MKP-5调节的疾病是一种纤维化疾病。
• COMPOUNDS AND COMPOSITIONS FOR TREATING FIBROSIS
  申请人：Yale University

  公开号：EP3732179A1

  公开（公告）日：2020-11-04
• Compounds and Compositions for Treating Fibrosis
  申请人：YALE UNIVERSITY

  公开号：US20200390770A1

  公开（公告）日：2020-12-17

  The present invention provides compounds and methods for treating, ameliorating, and/or preventing a MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease.