1-[(3aR,5S,6R,6aR)-6-azido-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,1,2,2-tetrol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(3aR,5S,6R,6aR)-6-azido-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,1,2,2-tetrol
• 化学式: C9H15N3O7
• 分子量: 277.23
• InChiKey: GCTVZUSGXFEPGE-ARQDHWQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• MONOSACCHARIDE DERIVATIVES
  申请人：Verma Kumar Ashwani

  公开号：US20070287673A1

  公开（公告）日：2007-12-13

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

  本发明涉及单糖衍生物作为抗炎药物。本文披露的化合物可用于抑制和预防炎症及相关病理，包括支气管哮喘、类风湿关节炎、I型糖尿病、多发性硬化、移植排斥、牛皮癣、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒和过敏性鼻炎等炎症和自身免疫疾病。还提供了含有本文披露的化合物的药理组合物以及治疗支气管哮喘、慢性阻塞性肺病、类风湿关节炎、多发性硬化、I型糖尿病、牛皮癣、移植排斥、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒、过敏性鼻炎和其他炎症和/或自身免疫疾病的方法。
• Monosaccharide derivatives
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1864992A2

  公开（公告）日：2007-12-12

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinids and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

  本发明涉及单糖衍生物作为抗炎症剂。本文披露的化合物可用于抑制和预防炎症及相关病理，包括支气管哮喘、类风湿关节炎、Ⅰ型糖尿病、多发性硬化、移植排斥、牛皮癣、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒症和过敏性鼻炎等炎症性和自身免疫性疾病。还提供了含有本文披露的化合物的药理组合物和治疗支气管哮喘、慢性阻塞性肺病、类风湿关节炎、多发性硬化、Ⅰ型糖尿病、牛皮癣、移植排斥、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒症、过敏性鼻炎和其他炎症和/或自身免疫性疾病的方法。
• US7790689B2
  申请人：——

  公开号：US7790689B2

  公开（公告）日：2010-09-07