3-[2-(4-Ethylphenyl)-2-oxoethyl]-6,7-dimethoxy-1(3H)-isobenzofuranone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[2-(4-Ethylphenyl)-2-oxoethyl]-6,7-dimethoxy-1(3H)-isobenzofuranone
• 英文别名: 3-[2-(4-ethylphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one
• 化学式: C₂₀H₂₀O₅
• 分子量: 340.4
• InChiKey: FLQDWYINAVROCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• METHODS OF IDENTIFYING AND TREATING IMMUNE CHECKPOINT INHIBITOR-RESPONSIVE NEOPLASMS AND CELLS, TRANSGENIC ANIMALS AND KITS FOR USE THEREIN
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20190085404A1

  公开（公告）日：2019-03-21

  Provided are methods of identifying whether a subject having cancer will be responsive to agents that combat immune evasion, such as immune checkpoint inhibitors. Methods of treating a subject having cancer are also provided. Such methods may include those that involve identifying whether the cancer will be responsive to an immune checkpoint inhibitor and/or is an immune-evasive cancer and administering an agent, e.g., an immune checkpoint inhibitor and/or a MYC inhibitor, to the subject to treat the cancer. Also provided are methods of identifying cancer therapeutics that are effective during MYC-regulated immune evasion as well as cancer cell lines and transgenic animals useful in such methods. Kits for use in the described methods are also provided.