memantine nitrate

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: memantine nitrate
• 英文别名: (3,5-Dimethyl-1-adamantyl)amine nitrate；3,5-dimethyladamantan-1-amine;nitric acid
• 化学式: C₁₂H₂₁N*HNO₃
• 分子量: 242.318
• InChiKey: YZQFRDLXENSKCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  92.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  memantine nitrate 在 硫酸 、 硝酸 、 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 生成 1-羟基-3-氨基-5,7-二甲基金刚烷盐酸盐
  参考文献：
  名称：

  金刚石烃一锅法合成桥头氨基醇

  摘要：

  摘要 已经开发出一种直接从笼形烃合成氨基醇的有效方法。多克可扩展性、良好的产量和一锅法，利用现成的试剂以及合成的便利性，显示了它的实用性。所提出的一锅法包括笼式烃与硝酸的连续反应，中间体硝基衍生物与尿素的进一步胺化，然后在添加浓溶液时将先前产生的胺氧化成氨基醇。H 2 SO 4。

  DOI：

  10.1080/00397911.2023.2177173
• 作为产物：
  描述：

  1,3-二甲基金刚烷 在 硝酸 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 4.0h， 生成 memantine nitrate
  参考文献：
  名称：

  金刚石烃一锅法合成桥头氨基醇

  摘要：

  摘要 已经开发出一种直接从笼形烃合成氨基醇的有效方法。多克可扩展性、良好的产量和一锅法，利用现成的试剂以及合成的便利性，显示了它的实用性。所提出的一锅法包括笼式烃与硝酸的连续反应，中间体硝基衍生物与尿素的进一步胺化，然后在添加浓溶液时将先前产生的胺氧化成氨基醇。H 2 SO 4。

  DOI：

  10.1080/00397911.2023.2177173

文献信息

• AMANTADINE NITRATE COMPOUND HAVING A NEUROPROTECTIVE EFFECT AND PREPARATION AND MEDICAL USE THEREOF
  申请人：Guangzhou Magpie Pharmaceuticals Co., Ltd.

  公开号：EP3150574A1

  公开（公告）日：2017-04-05

  The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (I). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.

  本发明涉及具有神经保护作用的金刚烷胺硝酸盐化合物，以及其制备方法和医用。这些化合物具有一般式（I）的结构。这些化合物具有多功能机制，包括抑制NMDA受体、释放NO、抑制钙离子通道进入以及对细胞特别是神经细胞具有保护作用。这些化合物可用于制备具有细胞保护作用的药物，用于预防或治疗与NMDA受体和细胞内钙离子升高相关的疾病，包括与神经退行性疾病相关的疾病，如阿尔茨海默病、帕金森病、脑瘫和青光眼，以及与心脑血管系统相关的疾病，如与脑动脉硬化相结合的帕金森综合征，以及由流感病毒引起的呼吸道感染。
• Amantadine nitrate compounds with neural protective effect, and preparation and medical use thereof
  申请人：Guangzhou Magpie Pharmaceuticals Co., Ltd.

  公开号：US20180148404A1

  公开（公告）日：2018-05-31

  The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (I). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.

  本发明涉及具有神经保护作用的金刚烷胺硝酸盐化合物，以及其制备方法和医药用途。这些化合物具有通用式（I）的结构。这些化合物具有多功能机制，包括抑制NMDA受体、释放NO、抑制钙离子流入，并对细胞特别是神经细胞具有保护作用。这些化合物可用于制备具有细胞保护作用的药物，用于预防或治疗与NMDA受体和细胞内钙离子升高相关的疾病，包括与神经退行性疾病如阿尔茨海默病、帕金森病、脑瘫和青光眼相关的疾病，以及与帕金森综合征合并脑动脉硬化、以及由流感病毒引起的呼吸道感染相关的心脑血管系统疾病。
• Amantadine nitrate compounds for use as medicaments for the treatment of diseases
  申请人：GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD.

  公开号：US11161800B2

  公开（公告）日：2021-11-02

  The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (II). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.

  本发明涉及具有神经保护作用的硝酸金刚烷胺化合物及其制备方法和医疗用途。这些化合物具有通式(II)的结构。 这些化合物具有多功能机制，包括抑制 NMDA 受体、释放 NO、抑制钙离子流入以及对细胞特别是神经细胞具有保护作用。这些化合物可用于制备具有细胞保护作用的药物，以预防或治疗与 NMDA 受体和细胞中钙阴离子升高有关的疾病，包括与神经变性有关的疾病，如阿尔茨海默病、帕金森病、脑瘫和青光眼；与心脑血管系统有关的疾病，如帕金森综合征合并脑动脉硬化；以及由流感病毒引起的呼吸道感染。
• AMANTADINE NITRATE COMPOUNDS FOR USE AS MEDICAMENTS FOR THE TREATMENT OF DISEASES
  申请人：GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD.

  公开号：US20190202772A1

  公开（公告）日：2019-07-04

  The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (II). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.
• [EN] THERAPEUTIC CONJUGATES AND METHODS OF USING SAME<br/>[FR] CONJUGUES THERAPEUTIQUES ET LEURS PROCEDES D'UTILISATION
  申请人：NEUROMOLECULAR PHARMACEUTICALS

  公开号：WO2007065036A2

  公开（公告）日：2007-06-07

  [EN] The present invention provides novel gabapentin-aminoadamantane derivative combinations (e.g. gabapentin-memantine) combinatorial compositions, methods of making the compositions, and methods for the treatment and prevention of neurological diseases, e.g., epilepsy, and neuropathic and chronic pain, using the compositions of the invention.
  [FR] La présente invention a trait à des combinaisons de dérivés gabapentines-aminoadamantanes (par exemple, la gabapentine-mémantine), à des compositions combinatoires, à des procédés de fabrication des compositions, et à des procédés pour le traitement de maladies neurologiques, par exemple, l'épilepsie, la douleur neuropathique et chronique, mettant en oeuvre les compositions de l'invention.