2-amino-9-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-1H-purine-6,8-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-amino-9-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-1H-purine-6,8-dione
• 化学式: C₁₃H₁₇N₅O₆
• 分子量: 339.3
• InChiKey: VDCRFBBZFHHYGT-YNJARDAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  161
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• IMMUNOMODULATORY CONJUGATES
  申请人：ASCEND BIOPHARMACEUTICALS LTD

  公开号：US20150030626A1

  公开（公告）日：2015-01-29

  The present invention provides an immunomodulatory compound comprising a carbohydrate polymer comprising mannose, wherein the carbohydrate polymer is conjugated to at least one immune modulator. The present invention also provides for the use of this compound in immunomodulatory compositions for vaccination and gene therapy methods, together with processes for its preparation.

  本发明提供了一种免疫调节化合物，包括一个含有甘露糖的碳水化合物聚合物，其中该碳水化合物聚合物与至少一种免疫调节剂结合。本发明还提供了该化合物在免疫调节组合物中用于疫苗和基因治疗方法的用途，以及其制备方法。
• Immunomodulatory conjugates
  申请人：ASCEND BIOPHARMACEUTICALS LTD

  公开号：US10344261B2

  公开（公告）日：2019-07-09

  The present invention provides an immunomodulatory compound comprising a carbohydrate polymer comprising mannose, wherein the carbohydrate polymer is conjugated to at least one immune modulator. The present invention also provides for the use of this compound in immunomodulatory compositions for vaccination and gene therapy methods, together with processes for its preparation.

  本发明提供了一种由包含甘露糖的碳水化合物聚合物组成的免疫调节化合物，其中该碳水化合物聚合物与至少一种免疫调节剂共轭。本发明还提供了这种化合物在免疫调节组合物中的用途，用于疫苗接种和基因治疗方法，以及其制备工艺。
• Compounds and compositions for treating EGFR expressing tumors
  申请人：BIRDIE BIOPHARMACEUTICALS, INC.

  公开号：US10548985B2

  公开（公告）日：2020-02-04

  Provided are compounds for targeted immunotherapy. The compounds are useful in the treatment of EGFR expressing tumors/cancers. Also provided are compositions comprising the compounds.

  本文提供了用于靶向免疫疗法的化合物。这些化合物可用于治疗表皮生长因子受体表达的肿瘤/癌症。还提供了包含这些化合物的组合物。
• Anti-HER2 combinations for treating tumors
  申请人：BIRDIE BIOPHARMACEUTICALS, INC.

  公开号：US11046781B2

  公开（公告）日：2021-06-29

  A combination which comprises an effective amount of Her2/Neu antagonist and an effective amount of immunotherapeutic that is capable of activating a human plasmacytoid dendritic cell, myeloid dendritic cell, NK cell, or a combination thereof is disclosed.

  本发明公开了一种组合物，其中包括有效量的 Her2/Neu 拮抗剂和有效量的能够激活人类浆细胞树突状细胞、髓样树突状细胞、NK 细胞或其组合的免疫疗法。
• Compounds and Compositions for Treating EGFR Expressing Tumors
  申请人：SHANGHAI BIRDIE BIOTECH, INC.

  公开号：US20160375148A1

  公开（公告）日：2016-12-29

  Provided are compounds for targeted immunotherapy. The compounds are useful in the treatment of EGFR expressing tumors/cancers. Also provided are compositions comprising the compounds.