8-Chloro-4,5-dihydro-5-methyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid | 71054-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-Chloro-4,5-dihydro-5-methyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid
• 英文别名: 8-chloro-5-methyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid
• CAS: 71054-81-4
• 化学式: C₁₃H₈ClNO₄
• 分子量: 277.664
• InChiKey: LIEHLLVDWHGBNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-氨基四氮唑 、 8-Chloro-4,5-dihydro-5-methyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid 在 2-ethoxy-1(2H)-quinolinecarboxylate 作用下， 生成 8-Chloro-4,5-dihydro-5-methyl-4-oxo-N-1H-tetrazol-5-ylpyrano[3,2-b]indole-2-carboxamide
  参考文献：
  名称：

  Synthesis and antiallergy activity of 4-oxopyrano[3,2-b]indoles

  摘要：

  A series of 4-oxopyrano[3,2-b]indole carboxylic acids, tetrazoles, and carboxamidotetrazoles has been prepared and tested for antiallergy potential in the rat passive cutaneous anaphylaxis (PCA) assay. Many of the compounds showed activity comparable or superior to that of cromolyn sodium or doxantrazole. Several compounds were orally active.

  DOI：

  10.1021/jm00185a023
• 作为产物：
  描述：

  ethyl 8-chloro-4,5-dihydro-5-methyl-4-oxopyrano[3,2-b]indole-2-carboxylate 在 盐酸 、 溶剂黄146 作用下， 反应 3.0h， 以31%的产率得到8-Chloro-4,5-dihydro-5-methyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and antiallergy activity of 4-oxopyrano[3,2-b]indoles

  摘要：

  A series of 4-oxopyrano[3,2-b]indole carboxylic acids, tetrazoles, and carboxamidotetrazoles has been prepared and tested for antiallergy potential in the rat passive cutaneous anaphylaxis (PCA) assay. Many of the compounds showed activity comparable or superior to that of cromolyn sodium or doxantrazole. Several compounds were orally active.

  DOI：

  10.1021/jm00185a023

文献信息

• Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic
  申请人：——

  公开号：US04316904A1

  公开（公告）日：1982-02-23

  Certain novel indolopyrone tetrazoles, carboxamidotetrazoles and their pharmaceutically acceptable salts are disclosed. These compounds are useful as antiallergic agents in mammals.

  某些新型吲哚吡喃四唑、羧酰胺基四唑及其药用盐被披露。这些化合物在哺乳动物中作为抗过敏药物是有用的。
• Process for the preparation of indolopyrones
  申请人：Warner-Lambert Company

  公开号：US04148806A1

  公开（公告）日：1979-04-10

  This invention relates to a novel process for preparing a group of novel substituted indolopyrones.

  本发明涉及一种制备一组新的取代吲哚并吡喃酮的新工艺。
• Indolopyrones having anti-allergic activity
  申请人：Warner-Lambert Company

  公开号：US04188326A1

  公开（公告）日：1980-02-12

  This invention relates to novel substituted indolopyrones which have utility in preventing allergic and asthmatic reactions in mammals.

  本发明涉及新型取代的吲哚吡喃，其在预防哺乳动物过敏和哮喘反应方面具有实用性。
• UNANGST P. C.; BROMN R. E.; HERZIG D. J., J. MED. CHEM., 1980, 23, NO 11, 1251-1255
  作者：UNANGST P. C.、 BROMN R. E.、 HERZIG D. J.

  DOI：——

  日期：——
• US4148806A
  申请人：——

  公开号：US4148806A

  公开（公告）日：1979-04-10