2-(3-Fluoro-4-methoxyphenyl)-1,3-dioxolane | 477980-84-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(3-Fluoro-4-methoxyphenyl)-1,3-dioxolane
• CAS: 477980-84-0
• 化学式: C₁₀H₁₁FO₃
• mdl: MFCD06208942
• 分子量: 198.194
• InChiKey: QTUSQNHJAUNRFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-Fluoro-4-methoxyphenyl)-1,3-dioxolane 在 lithium aluminium tetrahydride 、 18-冠醚-6 、 palladium 10% on activated carbon 、 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 、 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 45.0h， 生成 3-[4-[2-[2-[4-(Hydroxymethyl)-2-methoxyphenyl]-5-methoxyphenyl]ethyl]-2-methoxyphenoxy]-4-methoxybenzaldehyde
  参考文献：
  名称：

  Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s

  摘要：

  Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.052
• 作为产物：
  描述：

  3-氟-4-甲氧基苯甲醛 、 乙二醇 、 水 在 二氯甲烷 、 水 、 magnesium sulfate 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以produced 2-(3-Fluoro-4-methoxy-phenyl)-[1,3]-dioxolane as a colorless oil (550 mg, 92%)的产率得到2-(3-Fluoro-4-methoxyphenyl)-1,3-dioxolane
  参考文献：
  名称：

  Modulators of peroxisome proliferator activated receptors

  摘要：

  本发明公开了一种由结构式（I）表示的化合物：其中Ar是取代或未取代的芳香族基团。Q是共价键，-CH2-或-CH2CH2-;W是取代或未取代的烷基或取代或未取代的异烷基连接基，长度为2-10个原子，优选为2-7个原子。苯环A可以选择性地用多达四个取代基取代R1和W，R1是（CH2）n-CH（OR2）-（CH2）mE1，-（CH）= C（OR2）-（CH2）mE，-（CH2）n-CH（Y）-（CH2）mE或（CH）= C（Y）-（CH2）mE;其中E是COOR3，C1-C3烷基腈，羧酰胺，磺酰胺，酰基磺酰胺或四唑，其中磺酰胺，酰基磺酰胺和四唑可以选择性地用一个或多个取代基取代，独立选择自C1-C6烷基，卤代烷基和芳基-C0-4-烷基的一个或多个取代基;R2是H，脂肪基，取代脂肪基，卤代烷基，芳基，取代芳基，-COR4，-COOR4，-CONR5R6，-C（S）R4，-C（S）OR4或C（S）NR5R6，R3是H，脂肪基，取代脂肪基，芳基或取代芳基。Y是O-，CH2-，-CH2CH2-或CH═CH-，并与苯环A中与R1相邻的碳原子键合。R4-R6独立地为H，脂肪基，取代脂肪基，芳基或取代芳基。n和m独立地为0、1或2。

  公开号：

  US07192982B2

文献信息

• HYDROPHILIC POLYMER DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER
  申请人：NOF Corporation

  公开号：EP3130587A1

  公开（公告）日：2017-02-15

  To provide a hydrophilic polymer derivative having an acetal linker whose hydrolysis rate at pH of a weakly acidic environment in the living body can be accurately controlled, and which does not liberate a low molecular weight substance other than the hydrophilic polymer chain and the drug or the like connected, more specifically, a low molecular weight aldehyde, at the time of hydrolysis. The present invention relates to a hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s + t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.

  提供一种具有缩醛连接体的亲水性聚合物衍生物，其在生物体内弱酸性环境的 pH 值下的水解速度可精确控制，并且在水解时不会释放出除亲水性聚合物链和药物或类似物连接的低分子量物质，更具体地说，不会释放出低分子量醛。本发明涉及一种亲水性聚合物衍生物，它具有由下式（1）表示的环状亚苄基缩醛连接体： 其中 R1 和 R6 各自独立地为氢原子或碳氢基团；R2、R3、R4 和 R5 各自独立地为取电子或供电子取代基或氢原子；X1 为化学活性官能团；P 为亲水性聚合物；s 为 1 或 2，t 为 0 或 1，s + t 为 1 或 2；w 为 1 至 8 的整数；Z1 和 Z2 各自独立地为选定的二价间隔物。
• MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1392637A2

  公开（公告）日：2004-03-03
• US7192982B2
  申请人：——

  公开号：US7192982B2

  公开（公告）日：2007-03-20
• [EN] MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS<br/>[FR] MODULATEURS DE RECEPTEURS ACTIVES PAR LE PROLIFERATEUR DE PEROXYSOME
  申请人：LILLY CO ELI

  公开号：WO2002100813A2

  公开（公告）日：2002-12-19

  Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH2-or-CH2CH2-; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W. R1 is (CH2)n-CH(OR2)-(CH2)mE, -(CH)=C(OR2)-(CH2)mE, -(CH2)n-CH(Y)-(CH2)mE or (CH)=C(Y)-(CH2)mE; wherein E is COOR3, C1-C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, -COR4, -COOR4, -CONR5R6, -C(S)R4, -C(S)OR4 or C(S)NR5R6. R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O-, CH2-, -CH2CH2- or CH=CH- and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.
• Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
  作者：Hiromi Sawada、Miki Okazaki、Daichi Morita、Teruo Kuroda、Kenji Matsuno、Yuichi Hashimoto、Hiroyuki Miyachi

  DOI：10.1016/j.bmcl.2012.10.052

  日期：2012.12

  Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated. (C) 2012 Elsevier Ltd. All rights reserved.