4'-amino-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,2'-6,8-dihydrochromene]-3'-carbonitrile | 1380516-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4'-amino-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,2'-6,8-dihydrochromene]-3'-carbonitrile
• CAS: 1380516-89-1
• 化学式: C₁₉H₁₇N₃O₃
• 分子量: 335.362
• InChiKey: YCBLVXYOOKFDRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  靛红 、 5,5-二甲基-1,3-环己二酮 、 丙二腈 在 (2-aminomethyl)phenol supported on hydroxyapatite-encapsulated-γ-Fe2O3 nanocatalyst 作用下， 以 水 为溶剂， 反应 0.17h， 以55%的产率得到4'-amino-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,2'-6,8-dihydrochromene]-3'-carbonitrile
  参考文献：
  名称：

  One-pot synthesis of 4H-benzo[b]pyrans and dihydropyrano[c]chromenes using inorganic–organic hybrid magnetic nanocatalyst in water

  摘要：

  The synthesized nanocatalyst in this work provides a green and useful method to obtain 4H-benzo[b]pyrans and dihydropyrano[c]chromenes in aqueous media. The catalyst shows environmental benign character, which can be easily prepared, stored, recovered without obvious significant loss of activity. Due to water-resistant and superparamagnetic nano-nature of the catalyst, it could be easily separated by the application of an external magnetic device and reused conveniently. The synthesized inorganic-organic hybrid nanocatalyst has fully been characterized by magnetic, adsorptive and thermal techniques (transmission and scanning electron microscopy (TEM & SEM), Fourier transform spectroscopy infrared (FTIR), thermo gravimetric analysis (TGA), X-ray Diffraction (XRD), Brunauer Emmett Teller (BET) and vibrational sampling magnetometer (VSM)), which reveal of the superparamagnetic nano-nature of the particles. In summary, the magnetically inorganic-organic hybrid nanocatalyst supported on hydroxyapatite encapsulated gamma-Fe2O3 was found to be quite excellent and clean catalytic system for the synthesis of 4H-benzopyrans and 2-amino-5-oxo-4-aryl-4,5-dihydropyrano[3.2-c]chromene-3-carbonitriles. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.03.023

文献信息

• One-pot synthesis of 4H-benzo[b]pyrans and dihydropyrano[c]chromenes using inorganic–organic hybrid magnetic nanocatalyst in water
  作者：Mehdi Khoobi、Leila Ma’mani、Faezeh Rezazadeh、Zeinab Zareie、Alireza Foroumadi、Ali Ramazani、Abbas Shafiee

  DOI：10.1016/j.molcata.2012.03.023

  日期：2012.7

  The synthesized nanocatalyst in this work provides a green and useful method to obtain 4H-benzo[b]pyrans and dihydropyrano[c]chromenes in aqueous media. The catalyst shows environmental benign character, which can be easily prepared, stored, recovered without obvious significant loss of activity. Due to water-resistant and superparamagnetic nano-nature of the catalyst, it could be easily separated by the application of an external magnetic device and reused conveniently. The synthesized inorganic-organic hybrid nanocatalyst has fully been characterized by magnetic, adsorptive and thermal techniques (transmission and scanning electron microscopy (TEM & SEM), Fourier transform spectroscopy infrared (FTIR), thermo gravimetric analysis (TGA), X-ray Diffraction (XRD), Brunauer Emmett Teller (BET) and vibrational sampling magnetometer (VSM)), which reveal of the superparamagnetic nano-nature of the particles. In summary, the magnetically inorganic-organic hybrid nanocatalyst supported on hydroxyapatite encapsulated gamma-Fe2O3 was found to be quite excellent and clean catalytic system for the synthesis of 4H-benzopyrans and 2-amino-5-oxo-4-aryl-4,5-dihydropyrano[3.2-c]chromene-3-carbonitriles. (C) 2012 Elsevier B.V. All rights reserved.