2-Hydroxy-2-phenacyl-5-phenyl-3(2H)-furanon | 70591-05-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Hydroxy-2-phenacyl-5-phenyl-3(2H)-furanon
• 英文别名: 2-Hydroxy-2-phenacyl-5-phenylfuran-3-one
• CAS: 70591-05-8
• 化学式: C₁₈H₁₄O₄
• 分子量: 294.307
• InChiKey: KDTHYVPVPSPOSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,6-二苯基己烷-1,3,4,6-四酮 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 2-Hydroxy-2-phenacyl-5-phenyl-3(2H)-furanon
  参考文献：
  名称：

  3（2 H）呋喃酮衍生物。1,3,4,6-四酮系列中的环链互变异构†

  摘要：

  在1,3,4,6-四酮系列环链的互变异构平衡1已经被检查和链形式的标识2和羟基呋喃酮3已经从完成1个H-NMR谱; 两者的相对贡献取决于结构以及溶剂。描述了涉及环状互变异构体3的1到3（2 H）呋喃酮4和5的转化。

  DOI：

  10.1002/jhet.5570160301

文献信息

• Transcription factor modulating compounds and methods of use thereof
  申请人：Levy Stuart B.

  公开号：US20090131401A1

  公开（公告）日：2009-05-21

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了可用作抗感染剂的取代苯并咪唑化合物，其可降低微生物的耐药性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及其制备的药物制剂，例如用于减少抗生素耐药性和抑制生物膜的制剂。
• TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：LEVY Stuart B.

  公开号：US20110230523A1

  公开（公告）日：2011-09-22

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了用作抗感染剂的取代苯并咪唑化合物，可以降低微生物的抗性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及制备其药物制剂，例如，在减少抗生素抗性和抑制生物膜方面的应用。
• Novel dipeptidyl peptidase IV inhibitors used for functionally influencing different cells and treating immunological, infammatory, neuronal, and other diseases
  申请人：Ansorge Siegfried

  公开号：US20070037785A1

  公开（公告）日：2007-02-15

  The present invention relates to substances capable of specifically inhibiting Gly-Pro-p-nitroanilide cleaving peptidases, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
• US7405235B2
  申请人：——

  公开号：US7405235B2

  公开（公告）日：2008-07-29
• 3(2<i>H</i>)Furanone derivatives. Ring-chain tautomerism in the 1,3,4,6-tetraketone series
  作者：M. Poje、K. Balenovic

  DOI：10.1002/jhet.5570160301

  日期：1979.4

  Ring-chain tautomeric equilibria in the 1,3,4,6-tetraketone series 1 have been examined and the identification of the chain-form 2 and hydroxyfuranone 3 has been accomplished from 1H-nmr spectra; the relative contribution of the two depends on the structure and also on the solvent. Conversions of 1 into 3(2H)furanones 4 and 5 involving the cyclic tautomer 3 are described.

  在1,3,4,6-四酮系列环链的互变异构平衡1已经被检查和链形式的标识2和羟基呋喃酮3已经从完成1个H-NMR谱; 两者的相对贡献取决于结构以及溶剂。描述了涉及环状互变异构体3的1到3（2 H）呋喃酮4和5的转化。