(2S,3R,4S,5S,6S)-6-[azido(hydroxy)methyl]oxane-2,3,4,5-tetrol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5S,6S)-6-[azido(hydroxy)methyl]oxane-2,3,4,5-tetrol
• 化学式: C6H11N3O6
• 分子量: 221.17
• InChiKey: YEHSYXLCIYFVLZ-MBHNDSTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• CONTRAST AGENTS
  申请人：Morisson-Iveson Veronique

  公开号：US20080260651A1

  公开（公告）日：2008-10-23

  The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic N-heterocyclic central moiety such as pyrrolidine or piperidine heterocycles allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging, in particular in X-ray imaging, and to contrast media containing such compounds.

  本发明涉及一类化合物以及含有这种化合物的诊断组合物，其中这些化合物是含碘化合物。更具体地说，这些含碘化合物是化学化合物，含有一个脂肪族N-杂环中心基团，如吡咯烷或哌啶杂环，允许将三个碘化苯基团与之结合。该发明还涉及将这种诊断组合物用作对比剂在诊断成像中的应用，特别是在X射线成像中，并且涉及含有这种化合物的对比介质。
• RAPID GLYCOPEPTIDE OPTIMIZATION VIA NEOGLYCOSYLATION
  申请人：Thorson Jon S.

  公开号：US20080114157A1

  公开（公告）日：2008-05-15

  The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomycin aglycon. In particular, the present invention provides a library of vancomycin analogs, where the member of the library comprises at least one vancomycin analog selected from 2′-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 3′-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 4′-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 6′-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 2′-N-acylbiphenyl-glucosyl vancomycin neoglycoside, 3′-N-acylbiphenoyl-glucosyl vancomycin neoglycoside, 4′-N-acylbiphenoyl-glucosyl vancomycin neoglycoside and 6′-N-acylbiphenoyl-glucosyl vancomycin neoglycoside.

  本发明一般涉及用于生成万古霉素类似物的方法和组合物。具体而言，本发明涉及通过糖基与万古霉素非糖基的化学选择性连接来生成万古霉素文库。特别地，本发明提供了一个万古霉素类似物文库，其中该文库的成员包括至少一种从2'-N-酰基癸酰基-葡萄糖基万古霉素新糖苷、3'-N-酰基癸酰基-葡萄糖基万古霉素新糖苷、4'-N-酰基癸酰基-葡萄糖基万古霉素新糖苷、6'-N-酰基癸酰基-葡萄糖基万古霉素新糖苷、2'-N-酰基联苯基-葡萄糖基万古霉素新糖苷、3'-N-酰基联苯基-葡萄糖基万古霉素新糖苷、4'-N-酰基联苯基-葡萄糖基万古霉素新糖苷和6'-N-酰基联苯基-葡萄糖基万古霉素新糖苷中选择的至少一种万古霉素类似物。
• Phase transfer catalyzed glycosidation of an indolocarbazole
  申请人：——

  公开号：US20020058803A1

  公开（公告）日：2002-05-16

  The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.

  本发明涉及一种新型糖苷化工艺，用于制造制备吲哚吡咯并咔唑衍生物的中间体，该衍生物可抑制肿瘤细胞的生长，因此可用于治疗哺乳动物的癌症等。
• PHASE TRANSFER CATALYZED GLYCOSIDATION OF AN INDOLOCARBAZOLE
  申请人：Merck & Co., Inc.

  公开号：EP1333826A2

  公开（公告）日：2003-08-13
• US6555677B2
  申请人：——

  公开号：US6555677B2

  公开（公告）日：2003-04-29