(2S,3R,4R,5R)-2-(7-azido-4-methoxy-3H-imidazo[4,5-d]pyridazin-2-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4R,5R)-2-(7-azido-4-methoxy-3H-imidazo[4,5-d]pyridazin-2-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
• 化学式: C12H15N7O5
• 分子量: 337.29
• InChiKey: DIAVVJIYKDHXIR-TUINKIHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  148
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Purine nucleoside analogues for treating Flaviviridae including hepatitis C
  申请人：Storer Richard

  公开号：US20050075309A1

  公开（公告）日：2005-04-07

  This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents.

  本发明涉及一种治疗宿主，尤其是感染丙型肝炎病毒、黄热病毒和/或猪瘟病毒的人类的方法，包括向该宿主施用有效量的抗HCV生物活性五元糖基噻唑核苷，其中五元糖基噻唑核苷基是一个可选取代的2-氮杂嘌呤。可选取代的五元糖基噻唑核苷，或其盐或前药，可以单独或与一个或多个可选取代的五元糖基噻唑核苷或其他抗病毒药物联合使用。
• PURINE NUCLEOSIDE ANALOGUES FOR TREATING FLAVIVIRIDAE INCLUDING HEPATITIS C
  申请人：Indenix Pharmaceuticals, Inc.

  公开号：US20140234251A1

  公开（公告）日：2014-08-21

  This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents.

  这项发明涉及一种治疗感染丙型肝炎病毒、黄热病毒和/或猪瘟病毒的宿主，特别是人类的方法，包括向该宿主施用一种抗HCV生物活性戊呋喃核苷，其中戊呋喃核苷碱基是一个可选择取代的2-氮杂嘌呤。可选择取代的戊呋喃核苷，或其盐或前药，可以单独或与一个或多个可选择取代的戊呋喃核苷或其他抗病毒药物联合使用。
• PURINE NUCLEOSIDE ANALOGUES FOR TREATING DISEASES CAUSED BY FLAVIVIRIDAE INCLUDING HEPATITIS C
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP1658302B1

  公开（公告）日：2010-08-25
• US8742101B2
  申请人：——

  公开号：US8742101B2

  公开（公告）日：2014-06-03
• US9186369B2
  申请人：——

  公开号：US9186369B2

  公开（公告）日：2015-11-17