6-氨基己基-N-乙酰基-B-D-*硫代葡萄糖胺负离子 | 51224-17-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-氨基己基-N-乙酰基-B-D-*硫代葡萄糖胺负离子
• 英文名称: 6-Aminohexyl 2-acetamido-2-deoxy-1-thiohexopyranoside
• 英文别名: N-[2-(6-aminohexylsulfanyl)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• CAS: 51224-17-0
• 化学式: C₁₄H₂₈N₂O₅S
• 分子量: 336.45
• InChiKey: GOCQRGQPUDASDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• [EN] COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS<br/>[FR] COMPOSITIONS ET MÉTHODES ASSURANT UNE MEILLEURE ABSORPTION INTESTINALE DE COMPOSÉS OLIGOMÈRES CONJUGUÉS
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2015188194A1

  公开（公告）日：2015-12-10

  Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods are provided for oral delivery of conjugated oligomeric compounds. In certain embodiments, the oligomeric compounds are conjugated to one or more N-acetylgalactosamines or N-acetylgalactosamine analogues.

  本文提供了用于非肠内递送共轭寡聚化合物的组合物和方法。在某些实施方式中，提供了用于口服递送共轭寡聚化合物的组合物和方法。在某些实施方式中，这些寡聚化合物与一个或多个N-乙酰半乳糖胺或N-乙酰半乳糖胺类似物共轭。
• [EN] CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS ANTISENS CONJUGUÉS ET LEUR UTILISATION
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2015179693A1

  公开（公告）日：2015-11-26

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the gomeric compounds are conjugated to N-Acetylgalactosamine or to N-Acetylgalactosamine analogues.

  本文提供了具有共轭基团的寡聚化合物。在某些实施例中，这些寡聚化合物与N-乙酰半乳糖或N-乙酰半乳糖类似物结合。
• COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US20170145424A1

  公开（公告）日：2017-05-25

  Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods are provided for oral delivery of conjugated oligomeric compounds. In certain embodiments, the oligomeric compounds are conjugated to one or more N-acetylgalactosamines or N-acetylgalactosamine analogues.
• CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US20210054017A1

  公开（公告）日：2021-02-25

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the gomeric compounds are conjugated to N-Acetylgalactosamine or to N-Acetylgalactosamine anaologues.