2-Propoxyethylcyclopentane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Propoxyethylcyclopentane
• 英文别名: 2-propoxyethylcyclopentane
• 化学式: C₁₀H₂₀O
• 分子量: 156.26
• InChiKey: OIXHSIFKVHDFCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES<br/>[FR] PROCÉDÉ ET APPAREIL DE SYNTHÈSE DE DIHYDROARTÉMISININE ET DE DÉRIVÉS D'ARTÉMISININE
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2015007693A1

  公开（公告）日：2015-01-22

  The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

  本发明涉及一种连续生产二氢青蒿素以及由二氢青蒿素衍生的青蒿素衍生物的方法，该方法利用青蒿素或二氢青蒿酸（DHAA）作为起始物质，并且涉及一种用于生产二氢青蒿素以及青蒿素衍生物的连续流反应器。发现在连续过程中将青蒿素还原为二氢青蒿素需要一种特殊类型的反应器和一种特殊的试剂组合，包括一种氢化物还原剂，至少一种活化剂（例如无机活化剂），至少一种固体碱，至少一种无极性溶剂以及至少一种C1-C5醇。
• Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2826779A1

  公开（公告）日：2015-01-21

  The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

  本发明涉及一种连续生产二氢青蒿素以及由二氢青蒿素衍生的青蒿素衍生物的方法，该方法利用青蒿素或二氢青蒿酸（DHAA）作为起始物质，并且涉及一种用于生产二氢青蒿素以及青蒿素衍生物的连续流反应器。发现在连续过程中将青蒿素还原为二氢青蒿素需要一种特殊类型的反应器以及包括氢化还原剂、至少一种活化剂（如无机活化剂）、至少一种固体碱、至少一种无水溶剂和至少一种C1-C5醇的特殊组合的试剂。
• METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften

  公开号：EP3022208B1

  公开（公告）日：2017-06-14
• US9802952B2
  申请人：——

  公开号：US9802952B2

  公开（公告）日：2017-10-31