1-[4-[(3-Hydroxy-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)sulfonyl]phenyl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[(3-Hydroxy-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)sulfonyl]phenyl]ethanone
• 英文别名: 1-[4-[(3-hydroxy-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)sulfonyl]phenyl]ethanone
• 化学式: C₁₅H₂₀N₂O₅S
• 分子量: 340.4
• InChiKey: DURVYABQVPFOHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] INHIBITING AN IMMUNE RESPONSE MEDIATED BY ONE OR MORE OF TLR2, RAGE, CCR5, CXCR4 AND CD4<br/>[FR] INHIBITION D'UNE RÉPONSE IMMUNITAIRE INDUITE PAR UN OU PLUSIEURS COMPOSANTS PARMI TLR2, RAGE, CCR5, CXCR4 ET CD4
  申请人：[en]CASSAVA SCIENCES, INC.

  公开号：WO2022098700A1

  公开（公告）日：2022-05-12

  A method of inhibiting an immune response mediated by one or more of TLR2, RAGE, CCR5, CXR4 and CD4 cell surface receptors of cells in recognized need is disclosed. The method contemplates administering to such cells an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) whose structure is defined within. In one embodiment, the cells to which the compound or its salt is administered exhibit a hyperinflammatory syndrome.