(4R,5S)-3-azido-2,4-diethoxy-5-methoxy-6-(phenylmethoxymethyl)oxane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R,5S)-3-azido-2,4-diethoxy-5-methoxy-6-(phenylmethoxymethyl)oxane
• 化学式: C18H27N3O5
• 分子量: 365.4
• InChiKey: VOZOJZDNNXFWON-PXUJOYAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Classes of Compounds that Interact with Integrins
  申请人：Meutermans Wim

  公开号：US20080176936A1

  公开（公告）日：2008-07-24

  A method of inhibiting or effecting the activity of an integral receptor which comprises contacting an integrin with a compound of formula I, or a pharmaceutically acceptable salt thereof; General Formula I Wherein the ring may be of any configuration; Z is sulphur, oxygen, CH 2 , NH, NR A or hydrogen, in the case where Z is hydrogen then R 1 is not present, R A is selected from the set defined for R 1 to R 5 , X is oxygen or NR A providing that at least one X of General Formula I is NR A , X may also combine independently with one of R 1 to R 5 to form an azide, R 1 to R 5 are independently selected from the group comprising H, —(CO)R 6 or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, wherein R 6 is selected from the group comprising an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, with the proviso that XR 2 or XR 3 or XR 4 or XR 5 is not NH 2 , with the further proviso that not more than one of R 2 to R 5 is hydrogen, where the group X is NR A and R A is not hydrogen, the groups R A and the corresponding group R 2 to R 5 may combine to form a cycle.
• CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS
  申请人：MEUTERMANS Wim

  公开号：US20110165700A1

  公开（公告）日：2011-07-07

  A method of inhibiting or effecting the activity of an integrin receptor comprises contacting an integrin with a pyranose of formula I, or a pharmaceutically acceptable salt thereof.