2-amino-9-[(2R,3R,4R,5R)-4-(azidomethoxy)-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-amino-9-[(2R,3R,4R,5R)-4-(azidomethoxy)-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• 化学式: C11H13FN8O4
• 分子量: 340.27
• InChiKey: KHPVQIORJRMDLJ-QYYRPYCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Methods And Solutions For Inhibiting Undesired Cleaving Of Labels
  申请人：GORDON STEVEN

  公开号：US20100159531A1

  公开（公告）日：2010-06-24

  The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

  本发明提供了方法和组合物，包括但不限于算法、计算机可读介质、计算机程序、设备和系统，用于利用从合成测序方法中获得的数据，确定核苷酸序列中核酸的身份。本发明的方法包括纠正在核苷酸测序过程中遇到的一个或多个现象，例如使用合成测序方法。这些现象包括但不限于序列领先、序列滞后、光谱串扰以及由于照明和/或滤波器响应变化而导致的噪声。
• Methods and compositions for incorporating nucleotides
  申请人：QIAGEN SCIENCES, LLC

  公开号：US11001887B2

  公开（公告）日：2021-05-11

  The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

  本发明提供了用于确定核苷酸序列中核酸身份的方法和组合物，包括但不限于算法、计算机可读介质、计算机程序、仪器和系统，这些方法和组合物使用的是例如从合成测序方法获得的数据。本发明的方法包括纠正核苷酸测序过程中遇到的一种或多种现象，例如使用合成测序方法。这些现象包括但不限于序列前导、序列滞后、光谱串扰以及照明和/或滤波器响应变化产生的噪声。
• Methods and Compositions for Incorporating Nucleotides
  申请人：QIAGEN SCIENCES, LLC

  公开号：US20200040391A1

  公开（公告）日：2020-02-06

  The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
• US8883999B2
  申请人：——

  公开号：US8883999B2

  公开（公告）日：2014-11-11
• US9909174B2
  申请人：——

  公开号：US9909174B2

  公开（公告）日：2018-03-06