1,1,1-Trifluoroicos-11-ene-2,3-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1,1-Trifluoroicos-11-ene-2,3-dione
• 英文别名: 1,1,1-trifluoroicos-11-ene-2,3-dione
• 化学式: C₂₀H₃₃F₃O₂
• 分子量: 362.5
• InChiKey: JPQKLWKOGWSRDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Proteomic analysis
  申请人：The Scripps Research Institute of an Assignment

  公开号：US20020064799A1

  公开（公告）日：2002-05-30

  The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

  本发明提供了用于分析蛋白质组的方法，例如细胞或裂解物。该分析基于具有特异性对蛋白质的活性形式的探针的使用，特别是酶和受体。这些探针可以通过不同的方式进行识别。根据本发明，提供了一种用于生成和筛选化合物库的方法，用于识别引物分子，并并行识别它们的生物学靶标。通过向一个或多个结合基团添加特定的功能性和/或基团，反应性功能性获得了对特定蛋白质和蛋白质类的结合亲和性和特异性。这种候选化合物库，本文称为活性探针（ABPs），用于筛选一个或多个所需的生物活性或靶标蛋白质。
• Detoxification of microbial virulence factors in oral cavity
  申请人：The Procter & Gamble Company

  公开号：US10156566B2

  公开（公告）日：2018-12-18

  A method for identifying constituents for detoxifying oral virulence factors and a method for determining the effectiveness of detoxifying agents.

  一种确定口腔致病因子解毒成分的方法和一种确定解毒剂有效性的方法。
• Protein profiling platform
  申请人：——

  公开号：US20020182651A1

  公开（公告）日：2002-12-05

  Methods and compositions are described for analyzing complex protein mixtures, such as proteomes, using activity-based probes. In particular, probes that specifically react with and bind to the active form of one or more target proteins are employed. Labeled peptides obtained from the labeled active target proteins can be used in screening and identification procedures, and can be related to the identity, presence, amount, or activity of active members of the desired target protein class. The methods and compositions described herein can be used, for example, to provide diagnostic information concerning pathogenic states, in identifying proteins that may act as therapeutic targets, and in drug discovery.

  本文介绍了利用基于活性的探针分析复杂蛋白质混合物（如蛋白质组）的方法和组合物。特别是采用了能与一种或多种目标蛋白质的活性形式特异性反应并结合的探针。从标记的活性目标蛋白中获得的标记肽可用于筛选和鉴定程序，并可与所需目标蛋白类的活性成员的特征、存在、数量或活性相关联。本文所述的方法和组合物可用于提供有关致病状态的诊断信息、鉴定可作为治疗靶点的蛋白质以及药物发现等。
• PROTEOMIC ANALYSIS USING ACTIVITY-BASED PROBE LIBRARIES
  申请人：The Scripps Research Institute

  公开号：EP1275006A2

  公开（公告）日：2003-01-15
• PROTEIN PROFILING PLATFORM
  申请人：Activx Biosciences, Inc.

  公开号：EP1370867B1

  公开（公告）日：2010-08-04