6-((2-Oxo-2-phenylethyl)amino)hexanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-((2-Oxo-2-phenylethyl)amino)hexanoic acid
• 英文别名: 6-(phenacylamino)hexanoic acid
• 化学式: C₁₄H₁₉NO₃
• 分子量: 249.3
• InChiKey: LAEGFVLQZUXWTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION
  申请人：Manoharan Muthiah

  公开号：US20120035115A1

  公开（公告）日：2012-02-09

  The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

  该发明涉及公式I或II的化合物：在一种实施方式中，该发明涉及化合物和用于将配体与寡核苷酸结合的过程。该发明进一步涉及治疗各种疾病和疾病的方法，例如病毒感染、细菌感染、寄生虫感染、癌症、过敏、自身免疫疾病、免疫缺陷和免疫抑制。
• [EN] IRINOTECAN IMMUNOASSAY<br/>[FR] IMMUNOESSAI D'IRINOTÉCAN
  申请人：SALADAX BIOMEDICAL INC

  公开号：WO2011071672A1

  公开（公告）日：2011-06-16

  Novel conjugates of the pharmaceutically active metabolite of irinotecan and novel immunogens derived from this pharmaceutically active metabolite and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of the pharmaceutically active metabolite of irinotecan in biological fluids.

  新型与伊立替康药物活性代谢物有关的共轭物，以及从这种药物活性代谢物衍生的新型免疫原和由这些免疫原产生的单克隆抗体，可用于生物体液中伊立替康药物活性代谢物的定量和监测的免疫测定中。
• RADIOLABELED PROSTATE SPECIFIC MEMBRANE ANTIGEN INHIBITORS
  申请人：Molecular Insight Pharmaceuticals

  公开号：US20150078998A1

  公开（公告）日：2015-03-19

  Compounds according to Formula I and Formula II are potent inhibitors of PSMA activity: Pharmaceutical compositions may include a complex of a radionuclide and a compound of Formula I or Formula II.

  公式 I 和公式 II 的化合物是 PSMA 活性的有效抑制剂：药物组合物可以包括放射性核素和公式 I 或公式 II 的化合物的复合物。
• IRINOTECAN IMMUNOASSAY
  申请人：Salamone Salvatore J.

  公开号：US20110165699A1

  公开（公告）日：2011-07-07

  Novel conjugates of the pharmaceutically active metabolite of irinotecan and novel immunogens derived from this pharmaceutically active metabolite and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of the pharmaceutically active metabolite of irinotecan in biological fluids.
• US8962580B2
  申请人：——

  公开号：US8962580B2

  公开（公告）日：2015-02-24