2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7-methyl-6-thioxo-6,9-dihydro-3H-purin-7-ium

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7-methyl-6-thioxo-6,9-dihydro-3H-purin-7-ium
• 英文别名: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-3H-purin-9-ium-6-thione
• 化学式: C11H16N5O4S+
• 分子量: 314.34
• InChiKey: RFHIWBUKNJIBSE-KQYNXXCUSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  161
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
  申请人：ModernaTX, Inc.

  公开号：EP3431485A1

  公开（公告）日：2019-01-23

  Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.

  本文提供了将生物分子（如修饰的核酸）送入细胞以调节蛋白质表达的组合物和方法。这些组合物和方法包括使用修饰的信使核糖核酸，可用于生产蛋白质。
• ATP-BINDING CASSETTE FAMILY CODING POLYRIBONUCLEOTIDES AND FORMULATIONS THEREOF
  申请人：Ethris GmbH

  公开号：EP3913054A2

  公开（公告）日：2021-11-24

  Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.

  本发明公开了编码肽、蛋白质、酶及其功能片段的多核苷酸。本发明公开的多核苷酸可有效地传递到器官，如肺，并在器官细胞内表达。本发明公开的多核苷酸可用于治疗与ATP结合盒（ABC）家族基因（如ABCA3）相关的疾病或病症。
• [EN] REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C–P BONDS<br/>[FR] RÉACTIFS ET LEUR UTILISATION POUR LA SYNTHÈSE ÉNANTIODIVERGENTE MODULAIRE DE LIAISONS C-P
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2021146391A1

  公开（公告）日：2021-07-22

  The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.