Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.
本文描述了一种在适当的pH和温度条件下通过交联化合物进行消除反应降解的
水凝胶。
水凝胶可以用于传递各种药物等物质。本发明提供了一种在暴露于生理条件下以非酶促过程降解为更小的可溶性组分的
水凝胶及其制备方法。
水凝胶是由在生理条件下经历消除反应的
交联剂制备而成,从而将
交联剂从
水凝胶的骨架上解离出来。本发明还涉及
交联剂本身以及制备本发明的
水凝胶的中间体。按照本发明的方法制备的可
生物降解的
水凝胶可以用于不同领域,包括
生物医学工程、吸收材料以及作为药物传递的载体。