6-氯-6-脱氧半乳糖 | 18465-32-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-氯-6-脱氧半乳糖
• 英文名称: 6-Chloro-6-deoxygalactose
• 英文别名: (2R,3S,4R,5S)-6-chloro-2,3,4,5-tetrahydroxyhexanal
• CAS: 18465-32-2
• 化学式: C₆H₁₁ClO₅
• 分子量: 198.6
• InChiKey: ZHVNVPHMOCWHHO-DPYQTVNSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
  申请人：Seattle Genetics, Inc.

  公开号：US20140031536A1

  公开（公告）日：2014-01-30

  The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.

  这项发明提供了一种减少核心岩藻糖基化的抗体和抗体衍生物制备的方法和组合物。
• 6-Chloro-6-deoxy-D-hexitols, their esters, their preparation, fertility control compositions containing them and their use in a contraceptive method
  申请人：TATE & LYLE PUBLIC LIMITED COMPANY

  公开号：EP0015652A1

  公开（公告）日：1980-09-17

  6-Chloro-6-deoxy-D-hexitols, a novel class of compounds, and their esters, possess male antifertility activity and are thus useful in antifertility compositions. They are prepared by reduction of 6-chloro-6-deoxy-D-hexoses.

  6-氯-6-脱氧-D-己糖醇是一类新型化合物，其酯类具有抗男性不育活性，因此可用于抗不育组合物中。它们是通过还原 6-氯-6-脱氧-D-己糖制备的。
• Process for the preparation of chlorodeoxysugars
  申请人：TATE & LYLE PATENT HOLDINGS LIMITED

  公开号：EP0015757A1

  公开（公告）日：1980-09-17

  A process for the preparation of a chlorodeoxy derivative of a reducing aldose having a primary hydroxy group in an exocyclic -CH20H group, in which the said primary hydroxy group is replaced by a chlorine atom to give a chlorodeoxy reducing sugar with a free anomeric centre, characterised in that the free reducing sugar is reacted with a reagent comprising an N,N-dialkyl (methaniminium) chloride obtained by reacting an N,N-dialkyl formamide with a chlorinating agent.

  一种用于制备外环-CH20H基团中具有伯羟基的还原性醛糖的氯脱氧衍生物的工艺，其中所述伯羟基被一个氯原子取代，从而得到具有游离异构中心的氯脱氧还原糖，其特征在于游离还原糖与一种试剂反应，该试剂包括通过使N,N-二烷基甲酰胺与氯化剂反应而得到的N,N-二烷基（甲亚胺）氯化物。
• Modified glycoprotein, protein-conjugate and process for the preparation thereof
  申请人：SynAffix B.V.

  公开号：US10072096B2

  公开（公告）日：2018-09-11

  The invention relates to a glycoprotein comprising an optionally fucosylated glycan according to formula (105) or (106), wherein Su(A)x is a modified sugar moiety comprising one or more functional groups A. Functional group A is independently selected from the group consisting of a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonated hydroxyacetamido group. The invention also relates to a glycoprotein-conjugate wherein a glycoprotein according to the invention is conjugated to a molecule of interest. Said molecule of interest may for example be an active substance. The invention further relates to a process for the preparation of a modified glycoprotein, and to a method for the preparation of a glycoprotein-conjugate. The invention particularly relates to modified antibodies, antibody-conjugates, antibody-drug conjugates and methods for the preparation thereof.

  本发明涉及一种糖蛋白，该糖蛋白包含符合式（105）或（106）的可选岩藻糖基化聚糖，其中Su(A)x是包含一个或多个官能团A的修饰糖分子，官能团A独立地选自硫醇基、卤素、磺酰氧基、卤代乙酰氨基、巯基乙酰氨基和磺化羟基乙酰氨基组成的组。本发明还涉及一种糖蛋白-共轭物，其中根据本发明的糖蛋白与相关分子共轭。所述相关分子可以是活性物质。本发明还涉及一种制备修饰糖蛋白的工艺，以及一种制备糖蛋白-结合物的方法。本发明尤其涉及修饰的抗体、抗体-轭合物、抗体-药物轭合物及其制备方法。
• Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
  申请人：SEATTLE GENETICS, INC.

  公开号：US10443035B2

  公开（公告）日：2019-10-15

  The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.

  本发明提供了制备核心岩藻糖基化减少的抗体和抗体衍生物的方法和组合物。