(3R,4S,5S,6R)-2-[2-(3,4-dihydroxyphenyl)ethoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4S,5S,6R)-2-[2-(3,4-dihydroxyphenyl)ethoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₁₄H₂₀O₈
• 分子量: 316.3
• InChiKey: PQQITYGQJLPDFC-RQICVUQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  140
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• TREATMENT OF EARLY STAGE PARKINSON'S DISEASE WITH A HYDROXYTYROSOL-CONTAINING POLYPHENOL FORMULATION
  申请人：Allevium Therapeutics, Inc.

  公开号：US20160374959A1

  公开（公告）日：2016-12-29

  The invention provides a method for treating a subject suffering from early stage Parkinson's disease with a pharmaceutical formulation containing an olive polyphenol composition. The olive polyphenol composition includes hydroxytyrosol and at least one additional olive polyphenol, and the hydroxytyrosol represents about 40 wt. % to about 90 wt. % of the olive polyphenol composition. The formulation is administered to the subject within the context of a dosing regimen that provides a daily dosage of the olive polyphenol composition in the range of 30 mg to about 2500 mg. The invention additionally provides a method for reducing the dose of an antiparkinsonism drug used in the treatment of early stage Parkinson's disease, as well as a pharmaceutical formulation for treating early stage Parkinson's disease.
• TREATMENT OF EARLY STAGE PARKINSON'S DISEASE WITH A HYDROXYTYROSOL-CONTAINING POLYPHENOL FORMULATION
  申请人：Allevium Therapeutics, Inc.

  公开号：US20170367995A1

  公开（公告）日：2017-12-28

  The invention provides a method for treating a subject suffering from early stage Parkinson's disease with a pharmaceutical formulation containing an olive polyphenol composition. The olive polyphenol composition includes hydroxytyrosol and at least one additional olive polyphenol, and the hydroxytyrosol represents about 40 wt. % to about 90 wt. % of the olive polyphenol composition. The formulation is administered to the subject within the context of a dosing regimen that provides a daily dosage of the olive polyphenol composition in the range of 30 mg to about 2500 mg. The invention additionally provides a method for reducing the dose of an antiparkinsonism drug used in the treatment of early stage Parkinson's disease, as well as a pharmaceutical formulation for treating early stage Parkinson's disease.
• [EN] TREATMENT OF EARLY STAGE PARKINSON'S DISEASE WITH A HYDROXYTYROSOL-CONTAINING POLYPHENOL FORMULATION<br/>[FR] TRAITEMENT DE LA MALADIE DE PARKINSON À UN STADE PRÉCOCE AVEC UNE FORMULATION DE POLYPHÉNOL CONTENANT DE L'HYDROXYTYROSOL
  申请人：ALLEVIUM THERAPEUTICS INC

  公开号：WO2017222598A1

  公开（公告）日：2017-12-28

  The invention provides a method for treating a subject suffering from early stage Parkinson's disease with a pharmaceutical formulation containing an olive polyphenol composition. The olive polyphenol composition includes hydroxytyrosol and at least one additional olive polyphenol, and the hydroxytyrosol represents about 40 wt.% to about 90 wt.% of the olive polyphenol composition. The formulation is administered to the subject within the context of a dosing regimen that provides a daily dosage of the olive polyphenol composition in the range of 30 mg to about 2500 mg. The invention additionally provides a method for reducing the dose of an antiparkinsonism drug used in the treatment of early stage Parkinson's disease, as well as a pharmaceutical formulation for treating early stage Parkinson's disease.