(2R,3R,4S,5S,6R)-2-(dimethylamino)-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5S,6R)-2-(dimethylamino)-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₈H₁₇NO₅
• 分子量: 207.22
• InChiKey: YWLWQPWGBZWCCB-JAJWTYFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• GLUCOPYRANOSIDE COMPOUND
  申请人：NOMURA Sumihiro

  公开号：US20120258913A1

  公开（公告）日：2012-10-11

  A compound of the formula: wherein Ring A and Ring B are: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring or an optionally substituted unsaturated fused heterobicyclic ring, or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, and Ring B are independently an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; X is a carbon atom or a nitrogen atom; Y is —(CH 2 ) n — (n is 1 or 2); or a pharmaceutically acceptable salt thereof, or a prodrug thereof.

  一种化合物的公式：其中环A和环B是：(1) 环A是一个可选取代的不饱和单环杂环，环B是一个可选取代的不饱和单环杂环、可选取代的不饱和融合杂双环或可选取代的苯环，(2) 环A是一个可选取代的苯环，环B是一个可选取代的不饱和单环杂环或可选取代的不饱和融合杂双环，或(3) 环A是一个可选取代的不饱和融合杂双环，环B是独立的可选取代的不饱和单环杂环、可选取代的不饱和融合杂双环或可选取代的苯环；X是一个碳原子或氮原子；Y是—(CH2)n—(n为1或2)；或其药学上可接受的盐或前药。
• Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation
  申请人：WATERS TECHNOLOGIES CORPORATION

  公开号：US11150248B2

  公开（公告）日：2021-10-19

  Methods for preparing labeled glycosylamines from a complex matrix are provided. The methodology includes the steps of: denaturing glycoproteins in a complex matrix to form a denatured complex matrix mixture; loading the denatured complex matrix mixture onto a MWCO filtration device; adding a glycosidase enzymatic solution onto the MWCO filtration device to form a deglycosylated complex matrix mixture comprising glycosylamines; collecting glycosylamines released from the MWCO filtration device; and derivatizing glycosylamines with a rapid tagging reagent to form a plurality of labeled glycosylamines suitable for detection in various liquid chromatography systems and detectors.

  提供了从复杂基质中制备标记糖基胺的方法。该方法包括以下步骤将复合基质中的糖蛋白变性，形成变性复合基质混合物；将变性复合基质混合物装入 MWCO 过滤装置；将糖苷酶酶解液加入 MWCO 过滤装置，形成包含糖基胺的脱糖复合基质混合物；收集从 MWCO 过滤装置中释放的糖基胺；用快速标记试剂衍生糖基胺，形成适合各种液相色谱系统和检测器检测的多种标记糖基胺。
• Methods for the rapid preparation of labeled glycosylamines and for the analysis of glycosylated biomolecules producing the same
  申请人：Waters Technologies Corporation

  公开号：US11371996B2

  公开（公告）日：2022-06-28

  Methods of analyzing glycosylated biomolecules include the steps of producing a deglycosylation mixture of biomolecules deglycosylated by natural or synthetic enzymatic or chemical techniques; providing a reagent solution having a labeling reagent in a polar aprotic, non-nucleophilic organic solvent; and mixing the deglycosylation mixture with the reagent solution in an excess of labeling reagent to produce derivatized glycosylamines. The method steps can be carried out purposefully without depletion of protein matter. A quenching solution can be added to the reaction mixture so that the pH of the reaction mixture is shifted to above 10. The yield of derivatized glycosylamines can be in an amount of about 80 to about 100 mole percent of the reaction mixture with minimal overlabeling, less than 0.2 mole percent. The derivizated glycosylamines can be separated from the reaction mixture and detected by chromatographic detection, fluorescence detection, mass spectrometry (“MS”), or Ultra Violet (“UV”) detection and/or a combination thereof.

  分析糖基化生物大分子的方法包括以下步骤：制备由天然或合成酶或化学技术脱糖的生物大分子组成的脱糖混合物；在极性非亲核有机溶剂中提供具有标记试剂的试剂溶液；以及将脱糖混合物与标记试剂过量的试剂溶液混合，生成衍生化的糖基化胺。这些方法步骤可以在不损耗蛋白质物质的情况下有目的地进行。可向反应混合物中加入淬灭溶液，使反应混合物的 pH 值升至 10 以上。衍生化糖基胺的产率可达到反应混合物的约 80 至约 100 摩尔%，且重叠标记最小，小于 0.2 摩尔%。衍生化的糖基胺可以从反应混合物中分离出来，并通过色谱检测、荧光检测、质谱（"MS"）或紫外线（"UV"）检测和/或它们的组合进行检测。
• METHODS FOR THE RAPID PREPARATION OF LABELED GLYCOSYLAMINES AND FOR THE ANALYSIS OF GLYCOSYLATED BIOMOLECULES PRODUCING THE SAME
  申请人：Waters Technologies Corporation

  公开号：EP3213056B1

  公开（公告）日：2020-08-12
• METHODS FOR THE RAPID PREPARATION OF LABELED GLYCOSYLAMINES FROM COMPLEX MATRICES USING MOLECULAR WEIGHT CUT OFF FILTRATION AND ON-FILTER DEGLYCOSYLATION
  申请人：WATERS TECHNOLOGIES CORPORATION

  公开号：US20190170761A1

  公开（公告）日：2019-06-06

  Methods for preparing labeled glycosylamines from a complex matrix are provided. The methodology includes the steps of: denaturing glycoproteins in a complex matrix to form a denatured complex matrix mixture; loading the denatured complex matrix mixture onto a MWCO filtration device; adding a glycosidase enzymatic solution onto the MWCO filtration device to form a deglycosylated complex matrix mixture comprising glycosylamines; collecting glycosylamines released from the MWCO filtration device; and derivatizing glycosylamines with a rapid tagging reagent to form a plurality of labeled glycosylamines suitable for detection in various liquid chromatography systems and detectors.