(3S,4S,6S)-2-(azidomethyl)-6-methoxyoxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,4S,6S)-2-(azidomethyl)-6-methoxyoxane-3,4,5-triol
• 化学式: C7H13N3O5
• 分子量: 219.2
• InChiKey: DITZTAYZVSZBCC-UACUTCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93.5
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• NOVEL USES OF D-MANNOPYRANOSE DERIVATIVES ACTIVATING ANGIOGENESIS
  申请人：Montero Jean-Louis

  公开号：US20110124558A1

  公开（公告）日：2011-05-26

  The invention relates to the use of certain derivatives of D-mannopyranoside for controlling angiogenesis. These compounds have a pro-angiogenic activity, and can particularly be used for preparing a pharmaceutical composition for treating cardiovascular diseases or for treating muscular atrophy. The invention also relates to certain D-mannopyranoside derivatives, to a pharmaceutical or cosmetic composition containing said derivatives, and to the use of such a cosmetic composition for preventing and/or treating hair loss.

  该发明涉及利用某些D-甘露聚糖衍生物来控制血管生成。这些化合物具有促血管生成活性，特别适用于制备用于治疗心血管疾病或肌肉萎缩的药物组合物。该发明还涉及某些D-甘露聚糖衍生物，含有该衍生物的药用或化妆品组合物，以及利用此类化妆品组合物预防和/或治疗脱发。
• Glucose derivative, and cell imaging method and imaging agent using said derivative
  申请人：HIROSAKI UNIVERSITY

  公开号：US10001487B2

  公开（公告）日：2018-06-19

  Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

  本发明提供了一种葡萄糖衍生物，它可通过膜糖转运系统进入细胞，由式（1）表示。还提供了一种成像剂和一种使用所述葡萄糖衍生物对细胞或细胞内分子进行成像的方法。此外，还提供了一种使用所述葡萄糖衍生物精确检测癌细胞的方法和一种用于所述方法的成像剂。更具体地说，提供了 D-葡萄糖衍生物和 L-葡萄糖衍生物，其中葡萄糖与具有香豆素骨架或醌骨架的荧光分子基团的 7 位结合。还提供了一种细胞成像剂和使用该衍生物的成像方法。还提供了一种癌细胞成像剂和使用 L-葡萄糖衍生物的成像方法。G 是选自以下式 (G1)-(G4) 的基团。
• POLYMERS
  申请人：Haddleton David M.

  公开号：US20090082224A1

  公开（公告）日：2009-03-26

  The application discloses a process for making a polymer having pendant side groups comprising: (i) polymerising an olefinically unsaturated monomer functionalised with (a) an azide group optionally protected by a protecting group, or (b) an alkyne group optionally protected by a protecting group, by living radical polymerisation, most preferably RAFT, transitional metal mediated living radical polymerisation (TMM-LRP) and/or atom transfer radical polymerisation, to produce a polymer intermediate; (ii) removing, when present, at least a portion of the total number of protecting groups from the polymer intermediate; (iii) reacting the polymer intermediate with at least one pendant side group moiety functionalised with (a) an alkyne group or (b) an azide group respectively so that the alkyne and azide groups react to attach the pendant side group to the polymer. Processes for making supports comprising pendant side groups, and polymers and supports prepared by the method are also disclosed.
• NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE
  申请人：HIROSAKI UNIVERSITY

  公开号：US20170122955A1

  公开（公告）日：2017-05-04

  Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
• US8197847B2
  申请人：——

  公开号：US8197847B2

  公开（公告）日：2012-06-12