4-Acetyl-2--thiazol | 21346-32-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Acetyl-2--thiazol
• 英文别名: 1-(2-pyridin-4-yl-thiazol-4-yl)-ethanone；1-(2-Pyridin-4-yl-1,3-thiazol-4-yl)ethanone
• CAS: 21346-32-7
• 化学式: C₁₀H₈N₂OS
• 分子量: 204.252
• InChiKey: WWXXAHGKFSQFRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硫代异烟酰胺 在 硫酸 、 sodium nitrite 作用下， 以 乙醇 为溶剂， 生成 4-Acetyl-2--thiazol
  参考文献：
  名称：

  Benkoe,A.; Levente,A., Justus Liebigs Annalen der Chemie, 1968, vol. 717, p. 148 - 153

  摘要：

  DOI：

文献信息

• Method for Augmenting B Cell Depletion
  申请人：Chan C. Andrew

  公开号：US20080075719A1

  公开（公告）日：2008-03-27

  The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing mediated by the B cell depleting agent. One method of promoting intravascular access is by the use of integrin antagonists. Methods of treating B cell disorders by this approach is also provided.
• TYROSINE DERIVATIVE
  申请人：Jackson David Y.

  公开号：US20090325962A1

  公开（公告）日：2009-12-31

  The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
• US7595399B2
  申请人：——

  公开号：US7595399B2

  公开（公告）日：2009-09-29
• US8962551B2
  申请人：——

  公开号：US8962551B2

  公开（公告）日：2015-02-24
• [EN] METHOD FOR AUGMENTING B CELL DEPLETION<br/>[FR] METHODE PERMETTANT D'AUGMENTER L'APPAUVRISSEMENT DES LYMPHOCYTES B
  申请人：GENENTECH INC

  公开号：WO2005113003A2

  公开（公告）日：2005-12-01

  The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing mediated by the B cell depleting agent. One method of promoting intravascular access is by the use of integrin antagonists. Methods of treating B cell disorders by this approach is also provided.