(2S,3R)-cis-2,3-epoxyheptane | 149117-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: (2S,3R)-cis-2,3-epoxyheptane
• 英文别名: cis-2.3-Epoxyheptan；InChI=1/C7H14O/c1-3-4-5-7-6(2)8-7/h6-7H,3-5H2,1-2H3/t6-,7+/m0/s；(2R,3S)-2-butyl-3-methyloxirane
• CAS: 149117-12-4
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: RAWZOXRFHKUFPX-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙酰乙酸甲酯 、 (2S,3R)-cis-2,3-epoxyheptane 、 正丁基锂 、 四氢呋喃 、 三氟化硼 、 乙醚 以65%的产率得到
  参考文献：
  名称：

  YAMAGUCHI, MASAHIKO;HIRAO, ICHIRO, CHEM. LETT., 1985, N 3, 337-338

  摘要：

  DOI：
• 作为产物：
  描述：

  顺-2-庚烯 、 间氯过氧苯甲酸 生成 (2S,3R)-cis-2,3-epoxyheptane
  参考文献：
  名称：

  KURTH, MARK J.;ABREO, MELWYN A., TETRAHEDRON LETT., 28,(1987) N 46, 5631-5634

  摘要：

  DOI：

文献信息

• Methods for Obtaining Optically Active Epoxides and Diols from 2,3-Disubstituted and 2,3-Trisubstituted Epoxides
  申请人：Botes Adriana Leonora

  公开号：US20080199912A1

  公开（公告）日：2008-08-21

  The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific internal epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining optically active internal epoxides and corresponding optically active internal diols.

  本发明提供了具有对映选择性内部环氧水解酶活性的酵母菌株和由这些酵母菌株的基因编码的多肽。本发明还涵盖编码这种多肽的核酸分子，含有这种核酸分子的载体以及含有这种载体的细胞。本发明还包括获得光学活性内部环氧化物及其相应的光学活性内部二醇的方法。
• Iron(<scp>ii</scp>)-α-keto acid complexes of tridentate ligands on gold nanoparticles: the effect of ligand geometry and immobilization on their dioxygen-dependent reactivity
  作者：Abhijit Bera、Debobrata Sheet、Tapan Kanti Paine

  DOI：10.1039/d2dt02433k

  日期：——

  prepared to probe the effect of immobilization on their ability to perform bioinspired oxidation reactions. All the complexes react with dioxygen to display the oxidative decarboxylation of the coordinated benzoylformate, but the complexes supported by 6Me3-TPMM and its thiol-appended ligand display faster reactivity compared to their analogues with the 6Me2-Me-BPA-derived ligands. In each case, an electrophilic

  两个单核非血红素铁 ( II )-苯甲酰甲酸酯 (BF) 配合物 [(6Me 2 -Me-BPA)Fe(BF)](ClO 4 ) ( 1a ) 和 [(6Me 3 -TPMM)Fe(BF)](ClO 4 ) ( 1b ) 三齿氮供体配体，双（（6-甲基吡啶-2-基）甲基）（N-甲基）胺（6Me 2 -Me-BPA）和三（2-（6-甲基）吡啶基）甲氧基甲烷(6Me 3 -TPMM)，被分离和表征。铁 ( II )-氯络合物的结构表征表明配体 6Me 2 -Me-BPA 以经向方式与铁 ( II ) 中心结合，而 6Me 3-TPMM 充当面部配体。两种配体都用末端硫醇功能化以固定在金纳米粒子 (AuNPs) 和相应的铁 ( II ) 配合物 [(6Me 2 -BPASH)Fe(BF)(ClO 4 )]@C 8 Au ( 2a ) 和 [制备 (6Me 3 -TPMSH)Fe(BF)(ClO 4
• Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
  申请人：——

  公开号：US20030148443A1

  公开（公告）日：2003-08-07

  The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.

  本发明涉及具有环氧化物水解酶活性的多肽、编码这些多肽的多核苷酸、与这些多肽结合的抗体以及制造和使用这些多核苷酸和多肽的方法。环氧化物水解酶用于催化环氧化物和炔氧化物水解为相应的二醇。
• Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
  申请人：——

  公开号：US20030148490A1

  公开（公告）日：2003-08-07

  The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.

  本发明涉及具有环氧化物水解酶活性的多肽、编码这些多肽的多核苷酸、与这些多肽结合的抗体以及制造和使用这些多核苷酸和多肽的方法。环氧化物水解酶用于催化环氧化物和炔氧化物水解为相应的二醇。
• Bioproduction of Chiral Epoxyalkanes using Styrene Monooxygenase from<i>Rhodococcus</i>sp. ST-10 (RhSMO)
  作者：Hiroshi Toda、Ryouta Imae、Nobuya Itoh

  DOI：10.1002/adsc.201400383

  日期：2014.11.3

  AbstractWe describe the enantioselective epoxidation of straight‐chain aliphatic alkenes using a biocatalytic system containing styrene monooxygenase from Rhodococcus sp. ST‐10 and alcohol dehydrogenase from Leifsonia sp. S749. The biocatalyzed enantiomeric epoxidation of 1‐hexene to (S)‐1,2‐epoxyhexane (>44.6 mM) using 2‐propanol as the hydrogen donor was achieved under optimized conditions. The biocatalyst had broad substrate specificity for various aliphatic alkenes, including terminal, internal, unfunctionalized, and di‐ and tri‐substituted alkenes. Here, we demonstrate that this biocatalytic system is suitable for the efficient production of enantioenriched (S)‐epoxyalkanes.magnified image

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