6-氯异喹啉 | 62882-02-4

• 物质功能分类: 医药中间体 - 异喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 6-氯异喹啉
• 英文名称: 6-chloroisoquinoline
• CAS: 62882-02-4
• 化学式: C₉H₆ClN
• mdl: MFCD09991646
• 分子量: 163.606
• InChiKey: NCJNOOHAQSFEJN-UHFFFAOYSA-N

物化性质

• 熔点：
  39-40 °C
• 沸点：
  38-39 °C
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933499090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  室温密封，干燥保存。

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 6-Chloroisoquinoline
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 6-Chloroisoquinoline
CAS number: 62882-02-4

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H6ClN
Molecular weight: 163.6

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  6-氯异喹啉 在 diborane(6) 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 6-氯-1,2,3,4-四氢异喹啉
  参考文献：
  名称：

  Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-Substituted 1,2,3,4-tetrahydroisoquinolines

  摘要：

  In a search for inhibitors of epinephrine biosynthesis as potential therapeutic agents, a series of 13 ring-chlorinated 1,2,3,4-tetrahydroisoquinolines was prepared. These compounds were tested initially for their ability to inhibit rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) in vitro. Enzyme-inhibitor dissociation constants, determined for the six most potent members of the series, indicated the following order of decreasing potency: 7,8-Cl2 greater than 6,7,8-Cl3 greater than 7-Cl approximately 5,6,7,8-Cl4 greater than 5,7,8-Cl3. These compounds were subsequently examined for PNMT-inhibiting activity in intact rats and mice. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (13, SK&F 64139) was the most potent member of the series both in vitro and in vivo and is currently undergoing clinical investigation.

  DOI：

  10.1021/jm00179a007
• 作为产物：
  描述：

  6-chloro-1H-indene 在 臭氧 、 二甲基硫 、 碳酸氢钠 、 ammonium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 21.0h， 以64%的产率得到6-氯异喹啉
  参考文献：
  名称：

  1-咪唑基（烷基）取代的二氢和四氢喹啉及其类似物：血栓烷A（2）合酶和芳香酶的双重抑制剂的合成和评价。

  摘要：

  一系列的1-咪唑基（烷基）取代的喹啉，异喹啉，萘，苯并[b]呋喃和苯并[b]噻吩衍生物被合成为血栓烷A（2）合酶的双重抑制剂（P450 TxA（2））和芳香化酶（P450 arom）。对这些酶的双重抑制可能是治疗乳腺肿瘤和预防转移的新策略。最有效的双重抑制剂5-（2-咪唑-1-基乙基）-7,8-二氢喹啉（31）（P450 TxA（2）：IC（50）= 0.29 microM; P450 arom：IC（50）= 0.50 microM）及其5、6饱和类似物30（P450 TxA（2）：IC（50）= 0.68 microM; P450 arom：IC（50）= 0.38 microM）对两种目标酶的抑制作用均比参考化合物强（dazoxiben：IC（50）= 1.1 microM；氨基谷氨酰胺：IC（50）= 18.5 microM）。为了确定体内活性，在大鼠中检查了所选化合物对血清TxB（2）浓度的影响。化合物30（8

  DOI：

  10.1021/jm991180u

文献信息

• [EN] INHIBITORS OF KRAS G12C<br/>[FR] INHIBITEURS DE K-RAS G12C
  申请人：ARAXES PHARMA LLC

  公开号：WO2015054572A1

  公开（公告）日：2015-04-16

  Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

  提供了作为G12C突变KRAS蛋白抑制剂活性的化合物。这些化合物具有以下结构（I）：或其药用可接受的盐、互变异构体、前药或立体异构体，其中R1、R2a、R3a、R3b、R4a、R4b、G1、G2、L1、L2、m1、m2、A、B、W、X、Y、Z和E如本文所定义。还提供了与制备和使用这些化合物相关的方法，包括含有这些化合物的药物组合物以及调节G12C突变KRAS蛋白活性以治疗癌症等疾病的方法。
• Synthesis of <i>N</i>-(Hetero)aryl Carbamates via CuI/MNAO Catalyzed Cross-Coupling of (Hetero)aryl Halides with Potassium Cyanate in Alcohols
  作者：S. Vijay Kumar、Dawei Ma

  DOI：10.1021/acs.joc.7b03175

  日期：2018.3.2

  to N-(hetero)aryl carbamates was developed through CuI/MNAO [2-((2-methylnaphthalen-1-yl)amino)-2-oxoacetic acid] catalyzed cross-coupling of (hetero)aryl chlorides with potassium cyanate in alcohols at 120–130 °C. This method utilizes broadly available substrates to afford various N-(hetero)aryl carbamates in good to excellent yields. Moreover, (hetero)aryl bromides and (hetero)aryl iodides were also

  通过CuI / MNAO [2-（（（2-甲基萘-1-基）氨基）-2-氧乙酸]]催化（杂）芳基氯化物与钾的交叉偶联，开发了一种N-（杂）芳基氨基甲酸酯的有效途径醇中的氰酸盐在120–130°C下。该方法利用广泛可用的底物以良好至优异的产率提供各种N-（杂）芳基氨基甲酸酯。此外，（杂）芳基溴化物和（杂）芳基碘化物也以低催化剂负载量和相对较低的温度反应以提供N-（杂）芳基氨基甲酸酯。
• Light‐Promoted Minisci Coupling Reaction of Ethers and Aza Aromatics Catalyzed by Au/TiO ₂ Heterogeneous Photocatalyst
  作者：Zhanchong Li、Liangying Wu、Jiabao Guo、Yifei Shao、Yang Song、Yuzhou Ding、Li Zhu、Xiaoquan Yao

  DOI：10.1002/cctc.202100298

  日期：2021.8.20

  light-promoted Minisci oxidative coupling reaction of ether and aza aromatics by using oxygen as green oxidant and only catalytic amount of acid as additive. The protocol shows a good functional group tolerance as well as good to excellent yields for various substrates. With mechanistic studies, Au/TiO2 nanocomposite proved to be an efficient photocatalyst to activate C−H bond via a SEO approach of heteroatoms

  在本文中，Au/TiO 2纳米复合材料被合成并用作有机反应的高效绿色光催化剂。通过溶剂热法制备了具有高活性（001）晶面的片状锐钛矿二氧化钛材料。然后通过液相还原法将金纳米粒子负载在TiO 2表面，得到具有良好光催化活性的Au/TiO 2材料。Au/TiO 2利用纳米复合材料作为光催化剂，以氧气为绿色氧化剂，仅以催化量的酸为添加剂，开发了醚和氮杂芳烃的光促进 Minisci 氧化偶联反应。该协议显示出良好的官能团耐受性以及各种底物的优良产量。通过机理研究，Au/TiO 2纳米复合材料被证明是一种通过杂原子的 SEO 方法激活 C-H 键的有效光催化剂。此外，固体半导体光催化剂表现出良好的回收性能，易于回收和再利用，且收率不会显着降低。
• Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions
  作者：Stuart Pearson、Shaun Fillery、Kristin Goldberg、Julie Demeritt、Jonathan Eden、Jonathan Finlayson、Anil Patel

  DOI：10.1055/s-0037-1610223

  日期：2018.12

  indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described. Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of

  摘要 使氨磺酰氯活化的异喹啉在3组分反应中与吲哚反应，生成二氢异喹啉衍生物的文库。使用差异保护基团策略，可以进一步衍生产品。还描述了使用几种不同方法合成异喹啉原料。 使氨磺酰氯活化的异喹啉在3组分反应中与吲哚反应，生成二氢异喹啉衍生物的文库。使用差异保护基团策略，可以进一步衍生产品。还描述了使用几种不同方法合成异喹啉原料。
• Asymmetric acyl-Mannich reaction of isoquinolines with α-(diazomethyl)phosphonate and diazoacetate catalyzed by chiral Brønsted acids
  作者：Wei Wu、Yan Wang、Jing Guo、Liu Cai、Yuan Chen、Yanmin Huang、Yungui Peng

  DOI：10.1039/d0cc03201h

  日期：——

  An efficient asymmetric acyl-Mannich reaction of isoquinolines with α-(diazomethyl)phosphonate and diazoacetate has been developed using chiral spiro phosphoric acids as catalysts. This reaction allowed the construction of a series of chiral 1,2-dihydroisoquinolines bearing a tertiary stereocenter at the C1 position with up to 98% yield and 99% ee.

  使用手性螺环磷酸作为催化剂，已经开发了异喹啉与α-（重氮甲基）膦酸酯和重氮乙酸酯的有效不对称酰基曼尼希反应。该反应允许构建一系列手性的1,2-二氢异喹啉，在C1位置带有叔立体中心，产率高达98％，ee高达99％。