4-Nitrophenyl2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-a-D-glucopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Nitrophenyl2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-a-D-glucopyranoside
• 英文别名: [5-acetamido-3,4-diacetyloxy-6-(4-nitrophenoxy)oxan-2-yl]methyl acetate
• 化学式: C20H24N2O11
• 分子量: 468.4
• InChiKey: IMQGAARHTLJIRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  172
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Reagents and methods for screening MPS I, II, IIIA, IIIB, IVA, VI, and VII
  申请人：University of Washington through its Center for Commercialization

  公开号：US10196668B2

  公开（公告）日：2019-02-05

  Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IV A, MPS-VI, and MPS VII. In one aspect, the invention provides methods for assaying one or more enzymes associated with a lysosomal storage disease. In a first embodiment, the method includes: (a) contacting a sample with a first solution to provide a solution comprising one or more lysosomal enzymes; (b) contacting the one or more lysosomal enzymes in solution with an enzyme substrate for each lysosomal enzyme to be analyzed and incubating the substrates with the enzymes for a time sufficient to provide a solution comprising an enzyme product for each lysosomal enzyme present in the sample.

  用于检测与溶酶体贮积疾病 MPS-I、MPS-II、MPS-IIIA、MPS-IIIB、MPS-IV A、MPS-VI 和 MPS VII 有关的酶的试剂、方法和试剂盒。在一个方面，本发明提供了检测与溶酶体贮积症相关的一种或多种酶的方法。在第一个实施方案中，该方法包括(a) 将样品与第一溶液接触，以提供包含一种或多种溶酶体酶的溶液；(b) 将溶液中的一种或多种溶酶体酶与待分析的每种溶酶体酶的酶底物接触，并将底物与酶孵育足够长的时间，以提供包含样品中存在的每种溶酶体酶的酶产物的溶液。
• REAGENTS AND METHODS FOR SCREENING MPS I, II, IIIA, IIIB, IVA, VI, AND VII
  申请人：University of Washington through its Center for Commercialization

  公开号：US20190144916A1

  公开（公告）日：2019-05-16

  Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IVA, MPS-VI, and MPS VII.