4-Methoxy-2-pentan-3-ylpyridine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methoxy-2-pentan-3-ylpyridine
• 英文别名: 4-methoxy-2-pentan-3-ylpyridine
• 化学式: C₁₁H₁₇NO
• 分子量: 179.26
• InChiKey: FHLVMULJDRTNNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Compositions and methods for inhibition of the JAK pathway
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US10556891B2

  公开（公告）日：2020-02-11

  Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

  本文公开了式 I 的化合物、含有这些化合物的组合物，以及这些化合物和组合物用于治疗调节 JAK 通路或抑制 JAK 激酶（尤其是 JAK 2 和 JAK3）具有治疗作用的疾病的方法。
• Azepin-2-one derivatives as RSV inhibitors
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10647711B2

  公开（公告）日：2020-05-12

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物或其药学上可接受的盐、酯或原药： 其可抑制呼吸道合胞病毒（RSV）。本发明进一步涉及包含上述化合物的药物组合物，用于给受 RSV 感染的患者用药。本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者 RSV 感染的方法。
• AZEPIN-2-ONE DERIVATIVES AS RSV INHIBITORS
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US20190152968A1

  公开（公告）日：2019-05-23

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
• COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20200216431A1

  公开（公告）日：2020-07-09

  Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
• US9566283B2
  申请人：——

  公开号：US9566283B2

  公开（公告）日：2017-02-14