6-溴-3,4,5-三羟基环己基-1-烯 | 42014-74-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-溴-3,4,5-三羟基环己基-1-烯
• 中文别名: 杜特尔特溴
• 英文名称: bromoconduritol
• 英文别名: 6-Bromocyclohex-4-ene-1,2,3-triol
• CAS: 42014-74-4
• 化学式: C₆H₉BrO₃
• 分子量: 209.04
• InChiKey: SUCAFEYLYXXTPF-UHFFFAOYSA-N

物化性质

• 熔点：
  115-118°C
• 沸点：
  291.6±40.0 °C(Predicted)
• 密度：
  1.989±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于水
• 稳定性/保质期：

  常规情况下不会分解，没有危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2906199090

文献信息

• Inhibitors of glycoprotein processing having anti retroviral activity
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0295538A2

  公开（公告）日：1988-12-21

  Castanospermine, swainsonine, deoxynojirimycin, deoxymannojirimycin, bromoconduritol, and tunicamycin, known inhibitors of glycoprotein processing, are disclosed to be effective in treating retroviral infections including HIV infections and are thus useful in the treatment of AIDS and ARC.

  已知的糖蛋白加工抑制剂 Castanospermine、swainsonine、deoxynojirimycin、deoxymannojirimycin、bromoconduritol 和 tunicamycin 可有效治疗包括 HIV 感染在内的逆转录病毒感染，因此可用于治疗艾滋病和 ARC。
• Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins GP300, P200, and P90/80
  申请人：Institut Pasteur

  公开号：US20010006641A1

  公开（公告）日：2001-07-05

  Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is a dimeric form of gp14O, the precursor of HIV-2 envelope glycoprotein, is probably formed by a pH dependent fusion in the endoplasmic reticulum. Such a doublet is also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. On the other hand, the envelope glycoprotein precursor of HIV-1 does not form a dimer during its processing. Experiments carried out with various inhibitors of oligosaccharide trimming enzymes suggest that transient dimerization of the glycoprotein precursor is required for its efficient transport to the Golgi apparatus and for its processing. The gp300 is useful for detecting antibodies to HIV-2 antigens in human body fluids and for raising antibodies to gp300.

  在人类免疫缺陷病毒 2 型（HIV-2）感染细胞中可检测到表观分子量分别为 300,000、140,000、125,000 和 36,000 的四种糖蛋白（gp300、gp140、gp125 和 gp36）。gp125 和 gp36 分别是 HIV-2 成熟病毒包膜糖蛋白的外膜和跨膜成分。gp300 是 gp14O 的二聚体形式，是 HIV-2 包膜糖蛋白的前体，可能是在内质网中通过 pH 依赖性融合形成的。在感染猿猴免疫缺陷病毒（SIV）（一种与 HIV-2 密切相关的病毒）的细胞中也能观察到这种双聚体。另一方面，HIV-1 的包膜糖蛋白前体在加工过程中不会形成二聚体。使用各种寡糖修饰酶抑制剂进行的实验表明，糖蛋白前体的短暂二聚化是其有效运输到高尔基体并进行加工所必需的。gp300 可用于检测人体液中的 HIV-2 抗原抗体，也可用于培养 gp300 抗体。
• Précurseur de la glycoprotéine d'enveloppe du rétrovirus HIV-2 et antigènes apparentés
  申请人：INSTITUT PASTEUR

  公开号：EP0354072B1

  公开（公告）日：1995-05-10
• GENERATION OF WATER-SOLUBLE CANNABINOID COMPOUNDS IN YEAST AND PLANT CELL SUSPENSION CULTURES AND COMPOSITIONS OF MATTER
  申请人：Trait Biosciences, Inc.

  公开号：EP3679153A1

  公开（公告）日：2020-07-15
• Immune complexes comprising proteins of human immunodeficiency virus type 2 (HIV-2), antibodies against proteins of HIV-2, methods and kits employing proteins of HIV-2, and immunogenic compositions comprising proteins of HIV-2
  申请人：Montagnier Luc

  公开号：US20070172927A1

  公开（公告）日：2007-07-26

  Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is a dimeric form of gp140, the precursor of HIV-2 envelope glycoprotein, is probably formed by a pH dependent fusion in the endoplasmic reticulum. Such a doublet is also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. On the other hand, the envelope glycoprotein precursor of HIV-1 does not form a dimer during its processing. Experiments carried out with various inhibitors of oligosaccharide trimming enzymes suggest that transient dimerization of the glycoprotein precursor is required for its efficient transport to the Golgi apparatus and for its processing. The gp300 is useful for detecting antibodies to HIV-2 antigens in human body fluids and for raising antibodies to gp300.