3-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)-1-[4-(1,3-thiazolidin-5-ylmethyl)phenyl]propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)-1-[4-(1,3-thiazolidin-5-ylmethyl)phenyl]propan-1-one
• 英文别名: 3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-1-[4-(1,3-thiazolidin-5-ylmethyl)phenyl]propan-1-one
• 化学式: C₂₃H₂₄N₂O₂S
• 分子量: 392.5
• InChiKey: CXVIPUCZEYQKPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  80.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS OF GENERATING HYPER INOS EXPRESSING CELLS AND USES THEREOF
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20140335105A1

  公开（公告）日：2014-11-13

  A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell.