3-(3-Oxopropyldisulfanyl)propanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(3-Oxopropyldisulfanyl)propanoic acid
• 英文别名: 3-(3-oxopropyldisulfanyl)propanoic acid
• 化学式: C₆H₁₀O₃S₂
• 分子量: 194.3
• InChiKey: SJPIYFIDUHXIHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SIALINSÄUREDERIVATE
  申请人：Brossmer, Reinhard

  公开号：EP2863925B1

  公开（公告）日：2016-09-14
• [EN] PERSONAL CARE COMPOSITIONS WITH ENHANCED SOLUBILITY ACTIVES<br/>[FR] COMPOSITIONS DE SOINS PERSONNELS AVEC DES AGENTS ACTIFS À SOLUBILITÉ AMÉLIORÉE
  申请人：UNILEVER IP HOLDINGS B V

  公开号：WO2021219376A1

  公开（公告）日：2021-11-04

  Topical personal care compositions containing NDAC and optionally cystine as actives, whereby the solubility of cystine is enhanced. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants.
• [EN] PROCESS OF MAKING N,N-DIACETYL-L-CYSTINE DISODIUM SALT FROM CYSTINE AND ACETYL CHLORIDE IN METHANOL IN THE PRESENCE OF SODIUM HYDROXIDE<br/>[FR] PROCÉDÉ DE PRODUCTION DU SEL DISODIQUE DE N,N-DIACÉTYL-L-CYSTINE À PARTIR DE CYSTINE ET DE CHLORURE D'ACÉTYLE DANS DU MÉTHANOL EN PRÉSENCE D'HYDROXYDE DE SODIUM
  申请人：UNILEVER IP HOLDINGS B V

  公开号：WO2021219377A1

  公开（公告）日：2021-11-04

  A process of making Ν,Ν'-diacetyl-L-Cystine disodium salt, the process comprising: (i) Mixing hydroxy alkane (between 0.5-100L, preferably between 0.5-10L, more preferably between 1-3L, most preferably 1 L per mol of cystine) with a sodium base (4.0 molar equivalents per mole of cystine) to form a cold solution at a temperature of from 5 to 10°C; (ii) Adding cystine (1 molar equivalent) to said cold solution and stirring, for a sufficient time, to form a basic cystine solution; (iii) Optionally, Cooling the cystine solution to 5°C; (iv) Adding acetyl chloride (2 molar equivalents per mole of cystine) portionwise, while maintaining the temperature between 3 and 50 °C, preferably between 5 and 35 °C, more preferably below 10°C, most preferably 5°C, thereby resulting in a white suspension; (v) Stirring said white suspension and allowing said suspension to warm up to a room temperature of 15°C to 50°C, preferably 20°C to 35°C, more preferably 20°C, thereby resulting in Ν,Ν'-diacetyl-L-Cystine disodium salt product dissolved in solution and sodium chloride by-product precipitated solid in said suspension. The present description discloses an exemplary process on a small laboratory scale (500 mg cystine educt; 688 mg product; 90% yield) (page 16; example 1).