1-chloro-4-(8-phenyloct-1-en-7-yn-2-yl)benzene | 1300040-84-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-chloro-4-(8-phenyloct-1-en-7-yn-2-yl)benzene
• CAS: 1300040-84-9
• 化学式: C₂₀H₁₉Cl
• 分子量: 294.824
• InChiKey: CRVZRQBQQHBNSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-chloro-4-(8-phenyloct-1-en-7-yn-2-yl)benzene 在 三氟甲磺酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.5h， 以68%的产率得到7-chloro-4a-methyl-9-phenyl-2,3,4,4a-tetrahydro-1H-fluorene
  参考文献：
  名称：

  Triflic acid-catalyzed cascade cyclization of arenyl enynes via acetylene-cation cyclization and Friedel–Crafts type reaction

  摘要：

  A novel triflic acid-catalyzed cascade cyclization of arenyl 1,7-enynes through acetylene-cation cyclization followed by Friedel-Crafts reaction has been described. Various fused poly carbocycles can be obtained in good to high yields under mild reaction conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.094
• 作为产物：
  描述：

  7-phenylhept-6-yn-1-ol 在 正丁基锂 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 生成 1-chloro-4-(8-phenyloct-1-en-7-yn-2-yl)benzene
  参考文献：
  名称：

  Triflic acid-catalyzed cascade cyclization of arenyl enynes via acetylene-cation cyclization and Friedel–Crafts type reaction

  摘要：

  A novel triflic acid-catalyzed cascade cyclization of arenyl 1,7-enynes through acetylene-cation cyclization followed by Friedel-Crafts reaction has been described. Various fused poly carbocycles can be obtained in good to high yields under mild reaction conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.094

文献信息

• Triflic acid-catalyzed cascade cyclization of arenyl enynes via acetylene-cation cyclization and Friedel–Crafts type reaction
  作者：Tienan Jin、Junichi Uchiyama、Masafumi Himuro、Yoshinori Yamamoto

  DOI：10.1016/j.tetlet.2010.10.094

  日期：2011.4

  A novel triflic acid-catalyzed cascade cyclization of arenyl 1,7-enynes through acetylene-cation cyclization followed by Friedel-Crafts reaction has been described. Various fused poly carbocycles can be obtained in good to high yields under mild reaction conditions. (C) 2010 Elsevier Ltd. All rights reserved.