(2R,3S,4R,5R,6S)-5-amino-2-(hydroxymethyl)-6-(2-nitrophenoxy)oxane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5R,6S)-5-amino-2-(hydroxymethyl)-6-(2-nitrophenoxy)oxane-3,4-diol
• 化学式: C12H16N2O7
• 分子量: 300.26
• InChiKey: FENJAXAXDQGPER-LZQZFOIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] ANTIBODIES TO IL-24<br/>[FR] ANTICORPS CONTRE L'IL-24
  申请人：ARGEN-X N V

  公开号：WO2016174153A1

  公开（公告）日：2016-11-03

  The present invention relates to antibodies and antigen binding fragments thereof which exhibit high affinity binding to the human IL-24 protein and also exhibit potent blocking of IL-24 signalling through the IL-22R1/IL-20R2 and/or the IL20R1/IL-20R2 receptor complex. Provided are methods of producing recombinant antibodies and antigen binding fragments, expression vectors, host cells and pharmatceutical compositions. Also provided are methods of treating or preventing dermatological and inflammatory conditions in a human patient, which comprises administering IL-24 antagonists.