2-oxododecanal | 17090-70-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-oxododecanal
• CAS: 17090-70-9
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: JJRNDTFZUMHHGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  十二醛 在 selenium(IV) oxide 作用下， 以 乙醇 为溶剂， 反应 14.0h， 以24%的产率得到2-oxododecanal
  参考文献：
  名称：

  Inactivation of Protein Farnesyltransferase by Active-Site-Targeted Dicarbonyl Compounds

  摘要：

  Upon farnesylation by protein farnesyltransferase (FTase), key proteins become compartmentalized in cells. For example, cell membrane localization is essential for the mitogenic role of mutant Ras protein, which acts as a switch for cancer cell proliferation. We repel? that alpha -dicarbonyl compounds derived from the isoprenoid skeleton or other hydrophobic groups potently obstruct farnesylation of a Ras model peptide by human recombinant FTase in vitro. A geranyl-derived isoprenoid diketone, 5.9-dimethyl-8-decene-2,3-dione, at 17 muM caused a 62% reduction in FTase activity after 30 minutes. A farnesyl-derived isoprenoid diketone, 5,9,13-trimethyl-8,12-tetradecadiene-2,3-dione, at 93 muM caused a 94% reduction after 30 minutes. Other dicarbonyl:compounds found to be effective against FTase in vitro were (+/-)-6-(camphorquinone-10-sulfonamido)-hexanoic acid, 4,4 ' -biphenyldiglyoxaldehyde, dehydroascorbic acid 6-palmitace, 2-oxododecanal, and phenylglyoxal. Higher concentrations of the alpha -dicarbonyl compound resulted in more rapid and more extensive inactivation. These findings demonstrate that ct-dicarbonyl compounds targeted to FTase interfere with protein farnesylation in vitro and may,lead to derivatives that have utility as chemotherapeutic agents.

  DOI：

  10.1002/1521-4184(200106)334:6<194::aid-ardp194>3.0.co;2-m

文献信息

• Lubricating compositions
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP1013749A2

  公开（公告）日：2000-06-28

  There is provided a lubricating composition including a lubricating base containing an asymmetric sulfurized oxymolybdenum dithiocarbamate of the formula (1); a symmetric sulfurized oxymolybdenum dithiocarbamate of the formula (2); and a phenolic or aminic antioxidant. (wherein R1 to R5 are each a hydrocarbon group, provided that R1 to R4 are not concurrently the same group; and X1 to X8 are each a sulfur atom or an oxygen atom.) This lubricating composition meets both the required solubility of additives in base oils and long drain properties concurrently.

  本发明提供了一种润滑组合物，该组合物包括含有式（1）不对称硫化氧钼二硫代氨基甲酸盐的润滑基；式（2）对称硫化氧钼二硫代氨基甲酸盐；以及酚类或氨基抗氧化剂。 (其中 R1 至 R5 各为一个烃基，但 R1 至 R4 不同时为同一基团；X1 至 X8 各为一个硫原子或氧原子）。 这种润滑油组合物既能满足添加剂在基础油中的溶解性要求，又能同时满足长换油期的性能要求。
• Lubricating composition for diesel engines
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP1041135A1

  公开（公告）日：2000-10-04

  In diesel engines, soot is produced by combustion and enters into the engine oil, preventing the engine lubricant from fully exercising its lubricity. The present invention provides a lubricating composition comprising a lubricating basestock, an organic molybdenum compound (A) and succinimide (B) having 0.01 or less of an IR spectrum absorbance peak intensity ratio α/β, wherein α represents an absorbance peak intensity at 1,550±10cm-1 and β represents an absorbance peak intensity at 1,700±10cm-1. Preferably, the organic molybdenum compound is the compound represented by the following formula (1) or formula (2): (wherein R1 to R8 each independently represent a hydrocarbon, and X1 to X8 each independently represent a sulfur atom or an oxygen atom), or a reaction product of an amine and a molybdenum compound having at least one pentavalent or hexavalent molybdenum atom.

  在柴油发动机中，燃烧产生的烟尘会进入发动机油中，使发动机润滑油无法充分发挥其润滑性能。本发明提供了一种润滑组合物，该组合物包括润滑基质、有机钼化合物（A）和琥珀酰亚胺（B），其红外光谱吸光峰强度比 α/β 为 0.01 或更小，其中 α 表示 1,550±10cm-1 处的吸光峰强度，β 表示 1,700±10cm-1 处的吸光峰强度。有机钼化合物最好是下式（1）或式（2）所代表的化合物： (其中 R1 至 R8 各自独立地代表烃，X1 至 X8 各自独立地代表硫原子或氧原子），或胺与至少具有一个五价或六价钼原子的钼化合物的反应产物。
• METAL HYDRIDE FINE PARTICLE, METHOD FOR PRODUCING SAME, LIQUID DISPERSION CONTAINING METAL HYDRIDE FINE PARTICLE, AND METALLIC MATERIAL
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP1640338A1

  公开（公告）日：2006-03-29

  It is to provide fine particles of copper, nickel or palladium hydride having an average particle diameter of at most 50 nm, which are hardly oxidized in the atmosphere and are excellent in storage stability and are thereby very suitable for formation of metallic materials, and their production process. Further, it is to provide a dispersion containing fine particles of copper, nickel or palladium hydride, which is excellent in storage stability, and a metallic material obtained by applying the dispersion, followed by baking. The fine particles of copper, nickel or palladium hydride and the dispersion thereof, to be obtained by the present invention, are applicable to various applications, and they can be used for e.g. formation and repair of printed wiring, etc. employing a dispersion, interlayer wiring in semiconductor packages, and joining of printed wiring boards and electronic components.

  本发明的目的是提供平均颗粒直径不超过 50 纳米的氢化铜、镍或钯的细颗粒，这种颗粒在大气中几乎不被氧化，储存稳定性极佳，因此非常适合形成金属材料及其生产工艺。此外，还要提供一种含有铜、镍或氢化钯细颗粒的分散液，这种分散液具有极佳的储存稳定性，以及一种通过使用该分散液，然后进行烘烤而获得的金属材料。通过本发明获得的氢化铜、镍或钯的细颗粒及其分散体适用于各种应用，例如，它们可用于使用分散体形成和修复印刷线路等，半导体封装中的层间布线，以及印刷线路板和电子元件的连接。
• METAL-CONTAINING FINE PARTICLE, LIQUID DISPERSION OF METAL-CONTAINING FINE PARTICLE, AND CONDUCTIVE METAL-CONTAINING MATERIAL
  申请人：Asahi Glass Company, Limited

  公开号：EP1724789A1

  公开（公告）日：2006-11-22

  To provide metal-containing fine particles having good dispersion stability, which have their surface coated with dispersants vaporizable even during firing at low temperatures, a fine particle dispersion having the above metal-containing fine particles dispersed therein, and an electroconductive metal-containing material having an excellent volume resistivity formed by using the fine particle dispersion. Metal-containing fine particles with their surface coated with at least two dispersants having different vaporization temperatures.

  提供具有良好分散稳定性的含金属细颗粒，其表面涂有分散剂，即使在低温烧制过程中也可蒸发；提供具有上述含金属细颗粒的细颗粒分散体；以及提供使用该细颗粒分散体形成的具有优异体积电阻率的导电金属材料。 含金属细颗粒表面涂有至少两种具有不同蒸发温度的分散剂。
• LUBRICATING OIL COMPOSITION FOR INTERNAL COMBUSTION ENGINE
  申请人：Adeka Corporation

  公开号：EP3480284A1

  公开（公告）日：2019-05-08

  The present invention provides an engine oil composition that contains a base oil containing a low amount of aromatic components and can maintain lubricity because an organic molybdenum compound barely decomposes during long-term use without containing high amounts of an antioxidant or a zinc dithiophosphate compound. In order to achieve this, the present invention provides an internal combustion engine lubricating oil composition containing a base oil that is a hydrocarbon oil containing less than 1% by mass of aromatic components and having a sulphur content of less than 20 ppm by mass; a specific organic molybdenum compound as a component (A) at 300 to 1500 ppm by mass as molybdenum atoms; and a borate ester compound as a component (B) at 100 to 1000 ppm by mass as boron atoms.

  本发明提供了一种发动机油组合物，该组合物含有一种芳香族成分含量较低的基础油，并且由于有机钼化合物在长期使用过程中几乎不会分解，因此能够保持润滑性，同时不含大量抗氧化剂或二硫代磷酸锌化合物。 为此，本发明提供了一种内燃机润滑油组合物，其中包含一种基础油，该基础油是一种芳香族成分含量小于 1%（质量分数）且硫含量小于 20 ppm（质量分数）的烃类油；一种特定的有机钼化合物，作为组分（A），钼原子含量为 300 至 1500 ppm（质量分数）；以及一种硼酸酯化合物，作为组分（B），硼原子含量为 100 至 1000 ppm（质量分数）。