Methyl 3-[3-(3-methoxy-3-oxopropyl)-1-methyl-2-oxoindol-3-yl]propanoate | 411237-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Methyl 3-[3-(3-methoxy-3-oxopropyl)-1-methyl-2-oxoindol-3-yl]propanoate
• CAS: 411237-60-0
• 化学式: C₁₇H₂₁NO₅
• 分子量: 319.357
• InChiKey: LMIJAJDMTKKQBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 3-[3-(3-methoxy-3-oxopropyl)-1-methyl-2-oxoindol-3-yl]propanoate 在 盐酸 作用下， 反应 3.0h， 以87%的产率得到3,3'-(1-methyl-2-oxo-indoline-3,3-diyl)-di-propionic acid
  参考文献：
  名称：

  Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach

  摘要：

  Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.06.004
• 作为产物：
  描述：

  N-甲基吲哚酮 、 丙烯酸甲酯（MA） 在 sodium amide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以89%的产率得到Methyl 3-[3-(3-methoxy-3-oxopropyl)-1-methyl-2-oxoindol-3-yl]propanoate
  参考文献：
  名称：

  Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach

  摘要：

  Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.06.004

文献信息

• Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach
  作者：Madhukar S. Chande、Ranjit S. Verma、Pravin A. Barve、Rahul R. Khanwelkar、R.B. Vaidya、K.B. Ajaikumar

  DOI：10.1016/j.ejmech.2005.06.004

  日期：2005.11

  Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile. (c) 2005 Elsevier SAS. All rights reserved.