1-[1-[(2R,4S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-yl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[1-[(2R,4S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-yl]ethanone
• 化学式: C12H16NO5+
• 分子量: 254.26
• InChiKey: YFLLEDOXFRAPQI-RUJICJSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  90.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
  申请人：Cornell University

  公开号：US20150072950A1

  公开（公告）日：2015-03-12

  The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

  本发明涉及烟酰胺核苷酸和烟酰胺核苷酸衍生物的组合物及其使用方法。在某些实施例中，本发明涉及制备烟酰胺核苷酰组的方法。在某些实施例中，本发明涉及含有烟酰胺核苷酰的药物组合物和营养补充剂。此外，在进一步的实施例中，本发明涉及使用烟酰胺核苷酸和烟酰胺核苷酸衍生物的方法，以促进细胞和组织内烟酰胺腺嘌呤二核苷酸（NAD +）水平的增加，从而改善细胞和组织的存活。
• SYNTHESES, ACTIVITIES, AND METHODS OF USE OF DIHYDRONICOTINAMIDE RIBOSIDE DERIVATIVES
  申请人：Cornell University

  公开号：US20180208619A1

  公开（公告）日：2018-07-26

  Disclosed is a compound of formula (I): wherein R 1 , R 2 , R 3 , and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD + production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
• US9321797B2
  申请人：——

  公开号：US9321797B2

  公开（公告）日：2016-04-26