[(3S,4S,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl 4-methylbenzenesulfonate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(3S,4S,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl 4-methylbenzenesulfonate
• 化学式: C₁₄H₂₀O₈S
• 分子量: 348.37
• InChiKey: DBMMVDKCWRGJEG-ISDWTXNASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE
  申请人：Hirosaki University

  公开号：EP3130596A1

  公开（公告）日：2017-02-15

  A purpose of the present invention is to provide a novel glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Another purpose of the present invention is to provide an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Yet another purpose of the present invention is to provide a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. The present invention provides D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1) - (G4) below.

  本发明的一个目的是提供一种新型葡萄糖衍生物，它可通过膜糖转运系统被带入细胞，由式（1）表示。本发明的另一个目的是提供一种成像剂和一种使用所述葡萄糖衍生物的细胞或细胞内分子成像方法。本发明的另一个目的是提供一种使用所述葡萄糖衍生物准确检测癌细胞的方法和用于所述方法的成像剂。本发明提供了 D-葡萄糖衍生物和 L-葡萄糖衍生物，其中葡萄糖与具有香豆素骨架或醌骨架的荧光分子基团的 7 位结合。还提供了一种细胞成像剂和使用该衍生物的成像方法。还提供了一种癌细胞成像剂和使用 L-葡萄糖衍生物的成像方法。G 是选自以下式 (G1) - (G4) 的基团。