1-(4-chlorophenyl)-2-((4-fluorophenyl)amino)ethanone | 146537-17-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-chlorophenyl)-2-((4-fluorophenyl)amino)ethanone
• 英文别名: 1-(4-Chlorophenyl)-2-(4-fluoroanilino)ethanone
• CAS: 146537-17-9
• 化学式: C₁₄H₁₁ClFNO
• 分子量: 263.699
• InChiKey: SGDPIUDUXDYPEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-chlorophenyl)-2-((4-fluorophenyl)amino)ethanone 在 sodium hydroxide 、 p-fluoroanilinium bromide 、 zinc(II) chloride 作用下， 以 乙醇 、 苯 为溶剂， 反应 30.0h， 生成 4-(4-Chlorophenyl)-1-(4-fluorophenyl)-2-methyl-pyrrole-3-carboxylic acid
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1,4-diarylpyrroles

  摘要：

  The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(92)90092-f
• 作为产物：
  描述：

  2'-溴-4-氯苯乙酮 、 4-氟苯胺 以 乙醇 为溶剂， 反应 4.0h， 以65%的产率得到1-(4-chlorophenyl)-2-((4-fluorophenyl)amino)ethanone
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1,4-diarylpyrroles

  摘要：

  The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(92)90092-f

文献信息

• Synthesis of substituted 1,3-diaryl-6,7-dihydro-1H-indol-4(5H)-ones from 1-aryl-2-arylaminoethanones
  作者：Selvam Kaladevi、Jeyaraman Sridhar、Brahmanandan Abhilashamole、Shanmugam Muthusubramanian、Nattamai Bhuvanesh

  DOI：10.1039/c4ra03975k

  日期：——

  A simple and novel method for the synthesis of 1,3-diaryl-6,7-dihydro-1H-indol-4(5H)-ones from 1-aryl-2-arylaminoethanones and substituted cyclohexane-1,3-diones through acetic acid mediated reaction is disclosed.

  本发明公开了一种以 1-芳基-2-芳基氨基乙酮和取代的环己烷-1,3-二酮为原料，通过醋酸介导反应合成 1,3-二芳基-6,7-二氢-1H-吲哚-4(5H)-酮的简单而新颖的方法。
• 一种三唑酰胺酮类杀菌剂，合成方法及其应用
  申请人：三峡大学

  公开号：CN106243053B

  公开（公告）日：2018-09-28

  本发明属于有机化工技术领域，特别是一种作为杀菌剂的三唑酰胺酮类化合物，所述杀菌剂化学结构式为：其中，取代基R1和R2为苯基或对氯苯基或对溴苯基或对氟苯基或邻氟苯基或邻氯苯基或2,4‑二氯苯基或2,4‑二氟苯基或叔丁基或邻甲基苯基或间氟苯基或对三氟甲基苯基或邻甲基对氯苯基及其他取代基，取代基位置、个数以及共轭位置不固定。合成方法为以1,2,4‑三唑‑1‑乙酸与α‑氨基酮衍生物在有机催化剂作用下经缩合反应，得到的一类新型三唑酰胺酮类化合物，本发明提供了一种步骤少、产率高的合成新方法以合成一类新型三唑酰氨酮类化合物，又因产物其表现出良好的抑菌活性，有利于作为杀菌剂的应用。
• Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1,4-diarylpyrroles
  作者：GC Porretta、M Biava、R Fioravanti、M Fischetti、C Melino、F Venza、P Bolle、B Tita

  DOI：10.1016/0223-5234(92)90092-f

  日期：1992.10

  The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.