3-Formyl-1H-indole-6-carboxamidine | 83783-19-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-Formyl-1H-indole-6-carboxamidine
• 英文别名: 3-formyl-1H-indole-6-carboximidamide
• CAS: 83783-19-1
• 化学式: C₁₀H₉N₃O
• 分子量: 187.201
• InChiKey: ARAFMVRTTSKQMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.7
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-氰基吲哚 在 盐酸 、 氨 、 三氯氧磷 作用下， 反应 5.0h， 生成 3-Formyl-1H-indole-6-carboxamidine
  参考文献：
  名称：

  Aromatic amidines. Comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin

  摘要：

  Two series of amidine derivatives consisting of a total of 24 compounds were examined for a correlation between their blocking effect on respiratory syncytial virus induced cell fusion and their inhibitory activity against selected trypsin-like protease. Although no correlation was evident between the two activities, several potentially important discoveries were made. A highly selective inhibitor of plasmin over thrombin (compound 10) was obtained, and a potent new blocker of virus-induced cell fusion (compound 22) was identified.

  DOI：

  10.1021/jm00356a036

文献信息

• Aromatic amidines. Comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin
  作者：R. R. Tidwell、J. D. Geratz、E. J. Dubovi

  DOI：10.1021/jm00356a036

  日期：1983.2

  Two series of amidine derivatives consisting of a total of 24 compounds were examined for a correlation between their blocking effect on respiratory syncytial virus induced cell fusion and their inhibitory activity against selected trypsin-like protease. Although no correlation was evident between the two activities, several potentially important discoveries were made. A highly selective inhibitor of plasmin over thrombin (compound 10) was obtained, and a potent new blocker of virus-induced cell fusion (compound 22) was identified.