6-[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexanoic acid | 1101858-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexanoic acid
• 英文别名: 6-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexanoic acid
• CAS: 1101858-29-0
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: XJLFWMNWRNIEIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙醇 、 6-[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexanoic acid 在 硫酸 作用下， 反应 24.0h， 生成 Ethyl 6-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexanoate
  参考文献：
  名称：

  Modulation of PPAR receptor subtype selectivity of the ligands: Aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety

  摘要：

  Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPAR alpha agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with lipophilic tail. Compound 13a was found to be a selective and potent PPAR alpha agonist. Further 1,3-dioxane-2-carboxylic acid derivative 20 was synthesized by replacing the tetramethylene spacer of NS-220, a selective PPAR alpha agonist with phenylene group and found to exhibit PPAR alpha/gamma dual agonism. These results suggest that compounds possessing polymethylene spacer between pharmacophore and lipophilic tail exhibit predominantly PPARa agonism whereas those with an aromatic phenylene spacer shows PPAR alpha/gamma dual agonism. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.062
• 作为产物：
  描述：

  2-[4-[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]butyl]propanedioic acid 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 5.0h， 生成 6-[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexanoic acid
  参考文献：
  名称：

  Modulation of PPAR receptor subtype selectivity of the ligands: Aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety

  摘要：

  Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPAR alpha agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with lipophilic tail. Compound 13a was found to be a selective and potent PPAR alpha agonist. Further 1,3-dioxane-2-carboxylic acid derivative 20 was synthesized by replacing the tetramethylene spacer of NS-220, a selective PPAR alpha agonist with phenylene group and found to exhibit PPAR alpha/gamma dual agonism. These results suggest that compounds possessing polymethylene spacer between pharmacophore and lipophilic tail exhibit predominantly PPARa agonism whereas those with an aromatic phenylene spacer shows PPAR alpha/gamma dual agonism. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.062