2-hydroxy-1-(4-morpholinophenyl)butan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxy-1-(4-morpholinophenyl)butan-1-one
• 英文别名: 2-Hydroxy-1-(4-morpholin-4-ylphenyl)butan-1-one；2-hydroxy-1-(4-morpholin-4-ylphenyl)butan-1-one
• 化学式: C₁₄H₁₉NO₃
• 分子量: 249.31
• InChiKey: VVDGQLJFIHNWFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(1,1-dimethoxy-2-hydroxybutyl)-phenylmorpholine 在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 6.0h， 以60%的产率得到2-hydroxy-1-(4-morpholinophenyl)butan-1-one
  参考文献：
  名称：

  [EN] SIMPLE OXIDATIVE FUNCTIONALIZATION OF ALKYL ARYL KETONES
  [FR] FONCTIONNALISATION OXYDATIVE SIMPLE DE CÉTONES D'ALKYLARYLE

  摘要：

  本发明涉及一种用于反应烷基芳基酮以获得相应的芳基环氧化物或α-官能化烷基芳基醚醇的过程，以及该过程获得的芳基环氧化物或α-官能化烷基芳基醚醇，以及该过程获得的α-官能化酮。

  公开号：

  WO2018197324A1

文献信息

• SIMPLE OXIDATIVE FUNCTIONALIZATION OF ALKYL ARYL KETONES
  申请人：IGM Group B.V.

  公开号：EP3395806A1

  公开（公告）日：2018-10-31

  The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or α-functionalized alkyl aryl ketal, the aryl oxirane or α-functionalized alkyl aryl ketal obtained by the process as well as the α-functionalized ketone obtained by the process.

  本发明涉及一种使烷基芳基酮发生反应，从而获得相应的芳基环氧乙烷或α官能化烷基芳基酮的工艺、通过该工艺获得的芳基环氧乙烷或α官能化烷基芳基酮以及通过该工艺获得的α官能化酮。
• Simple oxidative functionalized of alkyl aryl ketones
  申请人：IGM GROUP B.V.

  公开号：US11203580B2

  公开（公告）日：2021-12-21

  The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or α-functionalized alkyl aryl ketal, the aryl oxirane or α-functionalized alkyl aryl ketal obtained by the process as well as the α-functionalized ketone obtained by the process.

  本发明涉及一种使烷基芳基酮发生反应，从而获得相应的芳基环氧乙烷或α官能化烷基芳基酮的工艺、通过该工艺获得的芳基环氧乙烷或α官能化烷基芳基酮以及通过该工艺获得的α官能化酮。
• SIMPLE OXIDATIVE FUNCTIONALIZED OF ALKYL ARYL KETONES
  申请人：IGM GROUP B.V.

  公开号：US20200031790A1

  公开（公告）日：2020-01-30

  The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or α-functionalized alkyl aryl ketal, the aryl oxirane or α-functionalized alkyl aryl ketal obtained by the process as well as the α-functionalized ketone obtained by the process.