1,3-bis-benzo[1,3]dioxol-5-ylpropenone | 76530-89-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-bis-benzo[1,3]dioxol-5-ylpropenone
• 英文别名: 1,3-Bis(1,3-benzodioxol-5-yl)prop-2-en-1-one
• CAS: 76530-89-7
• 化学式: C₁₇H₁₂O₅
• 分子量: 296.279
• InChiKey: BJVBIPGXQAUWBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  1,3-bis-benzo[1,3]dioxol-5-ylpropenone 在 bismuth(lll) trifluoromethanesulfonate 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 (E)-1,2-methylenedioxy-4-(3-(3,4-methylenedioxyphenyl)allyl)benzene
  参考文献：
  名称：

  Bi（OTf）3催化肉桂醇歧化反应

  摘要：

  肉桂醇的Bi（OTf）3催化歧化反应可提供查耳酮和苄基苯乙烯。本文研究了各种金属三氟甲磺酸酯用于简便有效的氧化还原转化的用途。已经提出了一种合理的机制。

  DOI：

  10.1016/j.tet.2017.05.006
• 作为产物：
  描述：

  胡椒醛 、 3,4-亚甲二氧苯乙酮 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 1,3-bis-benzo[1,3]dioxol-5-ylpropenone
  参考文献：
  名称：

  AIBN 和烯丙醇的铜催化克莱森重排

  摘要：

  开发了一种以 AIBN 为腈源的烯丙醇合成N-氰甲基酰胺的新方法。由于与铜催化剂的配位作用，通过异丁腈自由基的偶联形成酮亚胺中间体。铜激活的酮亚胺随后可以被烯丙醇拦截并进行克莱森重排以提供N -氰甲基酰胺。还描述了N -氰甲基酰胺产物的进一步官能团转化。

  DOI：

  10.1021/acs.joc.2c02298

文献信息

• Synthesis and characterization of some chalcones and their cyclohexenone derivatives
  作者：Thekke Sreevidya、Badiadka Narayana、Hemmige Yathirajan

  DOI：10.2478/s11532-009-0124-x

  日期：2010.2.1

  A series of chalcones and their derivatives have been synthesized. Chalcones, 1-(1,3-benzodioxol-5-yl)-3-(aryl)-prop-2-en-1-ones were prepared by the aldol condensation of 1-(1,3-benzodioxol-5-yl)ethanones and aryl aldehydes. Based-catalyzed condensation of 1-(1,3-benzodioxol-5-yl)-3-(aryl)prop-2-en-1-ones with ethyl acetoacetate yields corresponding ethyl 4-(1,3-benzodioxol-5-yl)-6-(aryl)-2-oxocyclohex-3-ene-1-carboxylates. Some of the synthesized chalcones were reported in the literature; the newly synthesized compounds were characterized by single crystal X-ray studies, IR, 1H-NMR and LCMS mass spectral analysis.

  摘要：一系列的查尔酮及其衍生物已经合成。查尔酮，1-(1,3-苯并二氧杂环戊烯-5-基)-3-(芳基)-丙-2-烯-1-酮通过1-(1,3-苯并二氧杂环戊烯-5-基)乙酮和芳基醛的醛缩反应合成。在碱性催化下，1-(1,3-苯并二氧杂环戊烯-5-基)-3-(芳基)丙-2-烯-1-酮与乙酰乙酸乙酯发生缩合反应，生成相应的乙酸乙酯 4-(1,3-苯并二氧杂环戊烯-5-基)-6-(芳基)-2-氧代环己-3-烯-1-羧酸酯。一些合成的查尔酮已在文献中报道；新合成的化合物通过单晶X射线衍射、红外光谱、核磁共振和液相质谱分析进行了表征。
• Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and parkinson's disease
  申请人：——

  公开号：US20040127555A1

  公开（公告）日：2004-07-01

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A&bgr; amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双和三羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成方法，包含它们的药物组成物，以及它们在治疗淀粉样疾病中的应用，特别是Aβ淀粉样蛋白病，如阿尔茨海默病，IAPP淀粉样蛋白病，如2型糖尿病中观察到的，以及突触核蛋白病，如帕金森病中观察到的，以及用于制造此类治疗药物。
• Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
  申请人：Snow D. Alan

  公开号：US20070225362A1

  公开（公告）日：2007-09-27

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双羟基和三羟基芳基化合物及其甲氧基二氧杂环化物和药学上可接受的酯类，它们的合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病，特别是阿尔茨海默病中观察到的Aβ淀粉样变性，IAPP淀粉样变性，例如在2型糖尿病中观察到的AA / SAA淀粉样变性，以及突触蛋白病，例如在帕金森病中观察到的应用，以及用于制造这种治疗药物。
• Compounds, compositions and methods for the treatment of synucleinopathies
  申请人：Esposito Luke

  公开号：US20070276034A1

  公开（公告）日：2007-11-29

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的制药组合物，以及它们在治疗突触核病，如帕金森病中的应用和制造用于这种治疗的药物。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE
  申请人：Snow Alan D.

  公开号：US20090069432A1

  公开（公告）日：2009-03-12

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其二氧化甲基类似物和药学上可接受的酯，它们的合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病中的应用，尤其是Aβ淀粉样蛋白病，如阿尔茨海默病，IAPP淀粉样蛋白病，如2型糖尿病，以及突触核病，如帕金森病，和用于制造这种治疗药物。