1,1-dimethoxy-hexan-2-ol | 53662-59-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-dimethoxy-hexan-2-ol
• 英文别名: 1,1-Dimethoxy-2-hexanol；1,1-dimethoxyhexan-2-ol
• CAS: 53662-59-2
• 化学式: C₈H₁₈O₃
• 分子量: 162.229
• InChiKey: VPLOFNSSGOHNTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2-bromo-1-methoxyhexyl) acetate 以98%的产率得到
  参考文献：
  名称：

  Boni Monica, Forti Luca, Gheifi Franco, Pagnoni Ugo M., Tetrahedron, 50 (1994) N 26, S 7897-7902

  摘要：

  DOI：

文献信息

• An efficient procedure to α-hydroxyaldehyde dimethyl acetals
  作者：Monica Boni、Luca Forti、Franco Ghelfi、Ugo M. Pagnoni

  DOI：10.1016/s0040-4020(01)85273-x

  日期：1994.1

  α-Hydroxyaldehyde dimethyl acetals are prepared efficiently by conversion of α-haloaldehyde dimethyl acetals into α-haloaldehyde hemiacetal acetates and subsequent methanolysis promoted by lithium methoxide.

  通过将α-卤代醛二甲基缩醛转化为α-卤代醛半缩醛乙酸酯并随后通过甲醇锂促进甲醇分解，可有效地制备α-羟基醛二甲基乙缩醛。
• PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS
  申请人：Mueller Thomas-Norbert

  公开号：US20100280276A1

  公开（公告）日：2010-11-04

  What is described is a process for preparing 2-hydroxyacetals of the general formula in which R 1 is hydrogen, a branched or unbranched C 1 -C 12 -alkyl radical, an electron-deficient, halogen-, NO 2 —, CN—, CF 3 —, acyl group- or branched or unbranched alkyl group-substituted or unsubstituted C 5 -C 6 -aryl or heteroaryl, and R 2 is a branched or unbranched C 1 -C 5 -alkyl radical, or both R 2 radicals are bonded directly to one another or to one another via a C 1 -C 4 unit, by reacting an enol compound of the general formula (II) in which R 3 is the same and R 1 is as defined for formula (Ia), with bromine to give the corresponding dibromo adduct and then reacting this dibromo adduct with an alkoxide of the general formula (III) M-O—R 2 (III) in which R 2 is as defined for formula (Ia) and O is oxygen and M is lithium, sodium or potassium. What is likewise described is the preparation of the corresponding 2-hydroxyalkanals from the 2-hydroxyacetals thus obtained by acidic hydrolysis.

  所描述的是一种制备2-羟基缩醛的过程，其一般式为R1为氢，支链或非支链C1-C12烷基基团，电子不足，卤素，NO2 -，CN -，CF3 -，酰基基团或支链或非支链烷基基团取代或未取代的C5-C6芳基或杂环芳基，R2为支链或非支链C1-C5烷基基团，或两个R2基团直接结合或通过C1-C4基团结合，通过将一般式（II）的烯醇化合物与溴反应得到相应的二溴加合物，然后将此二溴加合物与一般式（III）M-O-R2（III）的烷氧化物反应，其中R2如Ia式中所定义，O为氧，M为锂，钠或钾。同样描述了通过酸性水解从获得的2-羟基缩醛制备相应的2-羟基烷醛的方法。
• Polymeric Alpha-Hydroxy Aldehyde and Ketone Reagents and Conjugation Method
  申请人：Culbertson Sean M.

  公开号：US20110230618A1

  公开（公告）日：2011-09-22

  Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

  本文提供了聚合物α-羟基醛或α-羟基酮试剂，可以与含胺化合物共轭，在单步反应中形成稳定的共轭物。在选定的实施例中，聚合物试剂本身包含内部质子抽取（碱性）功能基团，以促进更有效的反应。通过连接剂必要时适当地定位取代基，以定位功能基团进行质子抽取，最好在α-碳上的氢原子和抽取原子之间提供4或5键间隔。还提供使用试剂的方法以及与生物活性化合物稳定、可溶化的共轭物。在优选实施例中，试剂或共轭物的聚合物组分是聚乙二醇。
• POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD
  申请人：NEKTAR THERAPEUTICS

  公开号：US20130280783A1

  公开（公告）日：2013-10-24

  Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

  本文提供了聚合物α-羟基醛或α-羟基酮试剂，可以与含胺化合物结合，形成稳定的共轭物，在单步反应中完成。在选定的实施例中，聚合物试剂本身包含一个内部质子抽取（碱性）功能基团，以促进更有效的反应。适当的取代基通过连接基团等方式进行定位，以将基团定位于质子抽取位置，最好在α-碳上的氢原子和抽取原子之间提供4或5键间隔。还提供了使用这些试剂和与生物活性化合物稳定、可溶化的共轭物的方法。在首选实施例中，试剂或共轭物的聚合物部分是聚乙二醇。
• Kirrmann et al., Bulletin de la Societe Chimique de France, 1958, p. 1469,1474
  作者：Kirrmann et al.

  DOI：——

  日期：——