4,5,5,6,6,6-Hexafluoro-4-(trifluoromethyl)hexan-1-ol | 239463-96-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,5,5,6,6,6-Hexafluoro-4-(trifluoromethyl)hexan-1-ol
• CAS: 239463-96-8
• 化学式: C₇H₇F₉O
• 分子量: 278.12
• InChiKey: WHNVWOCZLNZDCM-UHFFFAOYSA-N

物化性质

• 沸点：
  83-84°C 35mm
• 密度：
  1.457±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• METHODS OF INDUCING ANESTHESIA
  申请人：The Regents of the University of California

  公开号：EP3329966A1

  公开（公告）日：2018-06-06

  The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering an effective amount of an anesthetic compound identified according to the present methods.

  本发明提供了通过确定麻醉剂的摩尔水溶性来确定麻醉剂对麻醉剂敏感受体的选择性的方法。本发明进一步提供了通过改变或修饰麻醉剂使其具有较高或较低的水溶性来调节麻醉剂对麻醉剂敏感受体的选择性的方法。本发明进一步提供了通过施用有效量的根据本方法鉴定的麻醉剂化合物诱导受试者麻醉的方法。