6-羟基-萘并[1,2-c]呋喃-1,3-二酮 | 53300-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 中文名称: 6-羟基-萘并[1,2-c]呋喃-1,3-二酮
• 英文名称: 5-hydroxy-naphthalene-1,2-dicarboxylic acid-anhydride
• 英文别名: 5-Hydroxy-naphthalin-1,2-dicarbonsaeure-anhydrid；5-Hydroxynaphthalenedicarboxylic anhydride；6-hydroxybenzo[e][2]benzofuran-1,3-dione
• CAS: 53300-36-0
• 化学式: C₁₂H₆O₄
• 分子量: 214.177
• InChiKey: GXTHFPLTRVFHTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-methoxy-3,4-dihydro-naphthalene-1,2-dicarboxylic acid-anhydride 在 氢溴酸 、 sulfur 、 溶剂黄146 作用下， 生成 6-羟基-萘并[1,2-c]呋喃-1,3-二酮
  参考文献：
  名称：

  The Synthesis of 5-Hydroxy-1,2-naphthalic Anhydride

  摘要：

  DOI：

  10.1021/ja01176a088

文献信息

• COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS
  申请人：Universität für Bodenkultur Wien

  公开号：EP3643305A1

  公开（公告）日：2020-04-29

  The invention relates to a composition comprising one or more inhibitors capable of inhibiting at least two of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase for use in selectively eliminating senescent cells. The invention further relates to an in vitro method of identifying senescent cells in a subject and to a method of identifying candidate compounds for the selective elimination of senescent cells.

  本发明涉及一种组合物，该组合物包含一种或多种抑制剂，能够抑制环氧合酶-1（COX-1）、环氧合酶-2（COX-2）和脂氧合酶中的至少两种，用于选择性地消除衰老细胞。本发明还涉及一种鉴定受试者衰老细胞的体外方法，以及一种鉴定用于选择性消除衰老细胞的候选化合物的方法。
• Heidelberger; Wiest, Cancer Research, 1951, vol. 11, p. 511,513
  作者：Heidelberger、Wiest

  DOI：——

  日期：——
• [EN] MESENCHYMAL STEM CELLS WITH ENHANCED THERAPEUTIC PROPERTIES<br/>[FR] CELLULES SOUCHES MÉSENCHYMATEUSES PRÉSENTANT DES PROPRIÉTÉS THÉRAPEUTIQUES AMÉLIORÉES
  申请人：CELLS FOR CELLS S A

  公开号：WO2021105926A2

  公开（公告）日：2021-06-03

  Mesenchymal stem cells with enhanced therapeutic properties. The present invention refers to a method for obtaining mesenchymal stem cells (MSCs) with enhanced immunosuppression, chondroprotection and chondrodifferentiation properties, and enhanced capability to promote the proliferation of chondrocytes. The method comprises contacting the MSCs; culturing MSC in a induction media supplemented with 0.01 to 100 µg/ml of an ATP-synthase inhibitor; and removing the induction media to obtain MSC with enhanced activity. Moreover, the present invention also refers to the MSCs themselves and to their use for cell therapy purposes, preferably for treating autoimmune and/or osteoarticular diseases.