6-脱氧-甘露-庚吡喃糖 | 40653-20-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-脱氧-甘露-庚吡喃糖
• 英文名称: 6-Deoxy-manno-heptopyranose
• 英文别名: (2S,3S,4R,5R)-2,3,4,5,7-pentahydroxyheptanal
• CAS: 40653-20-1
• 化学式: C₇H₁₄O₆
• 分子量: 194.18
• InChiKey: YTDXCLRWYXTNRN-DBRKOABJSA-N

物化性质

• 沸点：
  515.3±50.0 °C(Predicted)
• 密度：
  1.488±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] TETRASACCHARIDES FOR THE DIAGNOSIS, PREVENTION, AND TREATMENT OF MELIOIDOSIS AND GLANDERS<br/>[FR] TÉTRASACCHARIDES POUR LE DIAGNOSTIC, LA PRÉVENTION ET LE TRAITEMENT DE LA MÉLIOÏDOSE ET DE LA MORVE
  申请人：INST NAT RECH SCIENT

  公开号：WO2020243815A1

  公开（公告）日：2020-12-10

  A tetrasaccharide of formula I and a method of production thereof are provided. Furthermore, a conjugate comprising the tetrasaccharide and a molecule attached to the tetrasaccharide, preferably via its amine group, is also provided. Compositions, preferably immunogenic or vaccine compositions, comprising this tetrasaccharide or this conjugate are also provided. Such tetrasaccharides, conjugates, and compositions can be used for preventing or treating a disease caused by a Burkholderia infection in a subject, for inducing the production of anti-Burkholderia antibodies in a subject, or for diagnosing a Burkholderia infection in a subject. Preferably, the Burkholderia infection is an infection by Burkholderia pseudomallei (Bp) or Burkholderia mallei (Bm); the disease is melioidosis or glander; and/or the anti-Burkholderia antibodies are anti-Burkholderia pseudomallei (Bp) antibodies or anti-Burkholderia mallei (Bm) antibodies.

  提供了一种具有式I的四糖和其生产方法。此外，还提供了包括该四糖和连接到该四糖上的分子（优选通过其胺基团连接）的共轭物。还提供了包括该四糖或该共轭物的组合物，优选为免疫原性或疫苗组合物。这些四糖、共轭物和组合物可用于预防或治疗由布氏杆菌感染引起的疾病，可用于在受试者中诱导抗布氏杆菌抗体的产生，或用于诊断受试者中的布氏杆菌感染。优选，布氏杆菌感染是由假痈疽布氏菌（Bp）或马勒布氏菌（Bm）引起的感染；疾病是痈疽病或疥疮；和/或抗布氏杆菌抗体是抗布氏假痈疽菌（Bp）抗体或抗布氏马勒菌（Bm）抗体。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• TETRASACCHARIDES FOR THE DIAGNOSIS, PREVENTION, AND TREATMENT OF MELIOIDOSIS AND GLANDERS
  申请人：Institut National de la Recherche Scientifique

  公开号：EP4007763A1

  公开（公告）日：2022-06-08
• METHOD OF DIAGNOSING AND TREATING MELIOIDOSIS
  申请人：Kozel Thomas

  公开号：US20130028927A1

  公开（公告）日：2013-01-31

  Non-invasive methods are provided herein for the diagnosis of melioidosis with specific antibodies capable of detecting molecules associated with melioidosis in a biological fluid, such as urine or serum. These molecules can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay. Methods of inducing an immune response to melioidosis are also disclosed. The methods include the use of the immunogenic melioidosis polypeptides, nucleic acids encoding these polypeptides, and/or viral vectors encoding an immunogenic melioidosis polypeptide, alone or in conjunction with other agents, such as traditional melioidosis therapies. Also disclosed are methods for treating a subject having melioidosis. These methods include inducing an immune response to melioidosis and/or using an inhibitory nucleic acid, such as a siRNA or antisense molecule, to decrease a melioidosis associated molecule expression in order to treat melioidosis.
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.