4-tert-butoxy-2-methyl-butan-2-ol | 22419-28-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-tert-butoxy-2-methyl-butan-2-ol
• 英文别名: 2-Butanol, 4-(1,1-dimethylethoxy)-2-methyl-；2-methyl-4-[(2-methylpropan-2-yl)oxy]butan-2-ol
• CAS: 22419-28-9
• 化学式: C₉H₂₀O₂
• 分子量: 160.257
• InChiKey: RVGRHAFZEQEHNE-UHFFFAOYSA-N

物化性质

• 沸点：
  185 °C
• 密度：
  0.91 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 包装等级：
  III
• 危险类别：
  3
• 危险性防范说明：
  P501,P240,P210,P233,P243,P241,P242,P264,P280,P370+P378,P337+P313,P305+P351+P338,P362+P364,P303+P361+P353,P332+P313,P403+P235
• 危险品运输编号：
  1993
• 危险性描述：
  H225,H315,H319

反应信息

• 作为反应物：
  描述：

  4-tert-butoxy-2-methyl-butan-2-ol 在 硫酸 作用下， 生成 异戊二醇 、 叔丁醇
  参考文献：
  名称：

  Ryvkina, L. A.; Sinitsyn, A. V.; Zakoshanskaya, L. A., Journal of applied chemistry of the USSR, 1991, vol. 64, # 10.2, p. 1991 - 1994

  摘要：

  DOI：
• 作为产物：
  描述：

  异戊二醇 、 叔丁醇 在 硫酸 作用下， 生成 4-tert-butoxy-2-methyl-butan-2-ol
  参考文献：
  名称：

  Ryvkina, L. A.; Sinitsyn, A. V.; Zakoshanskaya, L. A., Journal of applied chemistry of the USSR, 1991, vol. 64, # 10.2, p. 1991 - 1994

  摘要：

  DOI：

文献信息

• Water-Soluble and Water-Insoluble, Ring Opening Metathesis Polymerization Products, Monomers and Related Methods
  申请人：Tew Gregory N.

  公开号：US20090082524A1

  公开（公告）日：2009-03-26

  The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof.

  这项发明提供了用于环氧烯烃开环重聚合的某些新型水溶性和不溶性单体，以及新型聚合物、组合物和产品，以及相关方法。
• THERMAL RESPONSIVE MOLECULE
  申请人：Koga Noboru

  公开号：US20110124916A1

  公开（公告）日：2011-05-26

  Provided is a thermal responsive molecule favorable as a thermal responsive low-molecular hydrogelling agent or the like that gels in response to heat. The thermal responsive molecule is characterized in that an amphiphilic side chain obtained by bonding a hydrophilic side chain such as triethylene glycol and a hydrophobic group such as an octyl group is introduced into a C 3 -symmetric disc-shaped molecular skeleton such as 1,3,5-benzenetriyltriurea. For example, the thermal responsive molecule is 1,1′,1″-(benzene-1,3,5-triyl)tris3-(2,5,8,11-tetraoxaheptadecan-17-yl)urea} or the like.

  提供的是一种热响应分子，可作为热响应低分子水凝胶剂等，对热作出凝胶反应。该热响应分子的特征在于，在诸如1,3,5-苯三甲酰脲等C3对称的扁平分子骨架中引入了一种两亲侧链，该侧链是通过将亲水性侧链（如三乙二醇）和亲疏性基团（如辛基）结合而成的。例如，该热响应分子是1,1'，1''-(苯-1,3,5-三基)三3-(2,5,8,11-四氧庚十七基)脲}或类似物。
• PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS
  申请人：SATYAM Apparao

  公开号：US20110274695A1

  公开（公告）日：2011-11-10

  The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.

  本发明提供公式(I)的化合物或其药学上可接受的盐。本发明还提供包括公式I的一个或多个化合物或其中间体以及一个或多个药学上可接受的载体、车载剂或稀释剂的制药组合物。本发明还提供制备方法和使用方法，包括包含公式I的NO释放前药、双重前药和相互前药的前药的使用方法。
• DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS
  申请人：Malecha James W.

  公开号：US20130053387A1

  公开（公告）日：2013-02-28

  Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

  本文披露了新的去氮去铁硫菌素聚醚（DADFT-PE）类似物化合物，以及包含它们的制药组合物，并作为金属螯合剂用于治疗疾病。同时，还提供了在人或动物体内螯合铁和其他金属的方法，用于治疗金属过载和毒性。
• N-(4-(AZAINDAZOL-6-YL)-PHENYL)-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS
  申请人：SANOFI

  公开号：US20160024097A1

  公开（公告）日：2016-01-28

  The present invention relates to N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides of the formula I, wherein Ar, n, X, Z, R1, R2 and R3 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds which modulate protein kinase activity, specifically the activity of serum and glucocorticoid regulated kinase (SGK), in particular of serum and glucocorticoid regulated kinase isoform 1 (SGK-1, SGK1), and are suitable for the treatment of diseases in which SGK activity is inappropriate, for example degenerative joint disorders or inflammatory processes such as osteoarthritis or rheumatism. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

  本发明涉及式I中的N-(4-(氮杂吲唑-6-基)-苯基)-磺酰胺，其中Ar、n、X、Z、R1、R2和R3在权利要求中指定了它们的含义。式I化合物是有价值的药理活性化合物，可以调节蛋白激酶活性，特别是血清和糖皮质激素调节激酶（SGK）的活性，特别是血清和糖皮质激素调节激酶亚型1（SGK-1，SGK1）的活性，并适用于治疗SGK活性不当的疾病，例如退行性关节疾病或炎症过程，如骨关节炎或风湿病。此外，本发明还涉及制备式I化合物的方法，它们作为药物的用途以及包含它们的制剂。