7-Methyl-1,4-dioxaspiro[4.5]decan-8-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-Methyl-1,4-dioxaspiro[4.5]decan-8-ol
• 化学式: C₉H₁₆O₃
• 分子量: 172.22
• InChiKey: LCTPUJDUSKCUMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 3-Desoxy-2-Methylene-Vitamin D Analogs and Their Uses
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20130102567A1

  公开（公告）日：2013-04-25

  This invention discloses 3-desoxy-2-methylene-vitamin D analogs, and specifically (20S)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D 3 and (20R)-3-desoxy-1α, 25-dihydroxy-2-methylene-vitamin D 3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to monocytes thus evidencing use as anti-cancer agents especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also exhibit relatively high calcemic activity evidencing use in the treatment of bone diseases.

  本发明公开了3-脱氧-2-亚甲基-维生素D类似物，尤其是(20S)-3-脱氧-1α,25-二羟基-2-亚甲基-维生素D3和(20R)-3-脱氧-1α,25-二羟基-2-亚甲基-维生素D3以及其医药用途。这些化合物具有相对较高的结合活性和显著抑制未分化细胞增殖并诱导其向单核细胞分化的活性，因此可用作抗癌剂，特别用于治疗或预防骨肉瘤、白血病、结肠癌、乳腺癌、皮肤癌或前列腺癌。这些化合物还具有相对较高的钙调活性，可用于治疗骨骼疾病。
• 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20130102573A1

  公开（公告）日：2013-04-25

  This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-vitamin D 3 and (20R)-25-hydroxy-2-methylene-vitamin D 3 , as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also have relatively high calcemic activities evidencing use in the treatment of bone diseases.

  本发明公开了2-亚甲基-维生素D类似物，特别是(20S)-25-羟基-2-亚甲基-维生素D3和(20R)-25-羟基-2-亚甲基-维生素D3，以及它们的药物用途。这些化合物具有相对较高的结合活性和显著的抑制未分化细胞增殖并诱导其向单核细胞分化的活性，因此可用作抗癌剂，特别用于治疗或预防骨肉瘤、白血病、结肠癌、乳腺癌、皮肤癌或前列腺癌。这些化合物还具有相对较高的升高血钙作用，表明可用于治疗骨骼疾病。
• Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1
  申请人：Aicher Thomas Daniel

  公开号：US20080275043A1

  公开（公告）日：2008-11-06

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明公开了具有11beta-HSD type 1拮抗活性的化合物的公式I：（I），以及制备这种化合物的方法。在另一实施例中，本发明公开了包含公式I化合物的制药组合物，以及将公式I和组合物用作药物治疗糖尿病，高血糖，肥胖症，高血压，高脂血症，综合征X和与高血糖有关的其他疾病的用途。
• CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：AICHER Thomas Daniel

  公开号：US20100184764A1

  公开（公告）日：2010-07-22

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明揭示了具有11beta-HSD type 1拮抗活性的I式化合物：（I），以及制备这种化合物的方法。在另一种实施方式中，本发明揭示了包括I式化合物的制药组合物，以及将I式和组合物用作药物治疗糖尿病，高血糖，肥胖症，高血压，高脂血症，X综合症和其他与高血糖有关的疾病的用途。
• US7713979B2
  申请人：——

  公开号：US7713979B2

  公开（公告）日：2010-05-11