3-(2-bromoacetyl)benzenesulfonyl Chloride | 439697-11-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-bromoacetyl)benzenesulfonyl Chloride
• CAS: 439697-11-7
• 化学式: C₈H₆BrClO₃S
• 分子量: 297.55
• InChiKey: PEELKXBLIYKZHI-UHFFFAOYSA-N

物化性质

• 沸点：
  391.8±22.0 °C(Predicted)
• 密度：
  1.742±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PHENYLTHIAZOLE AND THIAZOLINE DERIVATIVES AND THEIR USE AS ANTIPARASITICS<br/>[FR] DERIVES DE PHENYLTHIAZOLE ET THIAZOLINE ET LEUR UTILISATION COMME ANTIPARASITES
  申请人：AKZO NOBEL NV

  公开号：WO2002051410A2

  公开（公告）日：2002-07-04

  The present invention provides a new class of antiparatisitcs. The compounds found with the present invention are substituted thiazole- and thiazoline derivatives. The present invention is based on the discovery that such compounds have been found to have antiparasitic activity. The present invention relates to 4-phenyl thiazole derivatives of the following general formula (I): X in formula (I) may be N-R6 or a bond. R1 in formula (I) may be (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl, (3-13C)heteroaryl, (6-14C)aryl(1-8C)alkyl or (3-13C)heteroaryl(1-8C)alkyl. R2 in formula (I) may be SO¿2?NR?7R8, CONR7R8 or NR7R8 R3 and R4¿ in formula (I) may independently be selected from H, halogen, (1-8C)alkyl, hydroxy, (1-8) alkoxy, cyano, nitro, (1-8C) alkoxycarbonyl, (1-8C)(di)alkylamino and (6-14C)(di)arylamino, or R?3 and R4¿ are joined together in a 5-7 membered carbocyclic or heterocyclic ring. R5 in formula (I) may be a halogen atom, (1-8C)alky, hydroxy, (1-8C)alkoxy, cyano, nitro, (1-8C)alkoxycarbonyl, (1-8C)(di)alkylamino or (6-14C)(di)arylamino. 'n' may be 0-3. R6 in formula (I) may be H or (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl, (3-13C)heteroaryl, (6-14C)aryl(1-8C)alkyl or (3-13C)heteroaryl(1-8C)alkyl. R?7 and R8¿ in formula (I) may independently be selected from H, (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl, (3-13C)heteroaryl, (6-14C)aryl(1-8C)alkyl and (3-13C)heteroaryl(1-8C)alkyl, or R?7 and R8¿ are joined together in a (2-7C) heterocycloalkyl ring.